Male gender bias in autism and pediatric autoimmunity.
Male gender bias in autism and pediatric autoimmunity.
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DOI：
10.1002/aur.1227
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发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Becker KG
中科院分区：
文献类型：
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作者：
Becker KG
男性自闭症的发病率比女性高约4比1。同样，与女性相比，男性患某些儿科自身免疫性疾病的发病率更高。这些差异的基础基本上是未知的。近年来，越来越多的证据表明免疫和自身免疫失调可能与自闭症有关。在这里建议，激素和免疫过程，可能有助于男性优势，在一些儿科自身免疫性疾病可能发挥作用，男性优势自闭症。自闭症和儿童自身免疫性疾病中的男性偏见被认为涉及遗传控制背景下怀孕或幼儿期的激素扰动。这些早期的分子事件，在快速发展的时候，与大脑和免疫系统的同步发展密切相关。这表明，这些早期的监管活动可能会重叠自闭症和自身免疫性在确定男性性别偏见，并可能提供证据的自闭症，免疫失调和自身免疫性疾病之间的病因联系。
Males have a higher incidence of autism than females by approximately 4 to 1. Similarly, males have a higher incidence of some pediatric autoimmune diseases as compared to females. The basis for these disparities is largely unknown. In recent years there is growing evidence that immune and autoimmune dysregulation may be involved in autism. It is suggested here that the hormonal and immune processes that may contribute to a male preponderance in some pediatric autoimmune disorders may play a role in the male preponderance in autism. Male bias in both autism and pediatric autoimmune disease is thought to involve hormonal perturbations in pregnancy or early childhood in the context of genetic control. These early molecular events, at a time of rapid development, are intimately linked to concurrent development in the brain and immune system. It is suggested here that these early regulatory events may overlap between autism and autoimmunity in determining male sex bias and may provide evidence of an etiological link between autism, immune dysregulation, and autoimmune disease.