DISTRIBUTION OF FIBRONECTIN AND LAMININ IN HUMAN-LIVER TUMORS
DISTRIBUTION OF FIBRONECTIN AND LAMININ IN HUMAN-LIVER TUMORS
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DOI：
10.1007/bf01884256
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发表时间：
1985-01-01
影响因子：
3.6
通讯作者：
LAPIS, K
中科院分区：
文献类型：
--
作者：
SZENDROI, M;LAPIS, K
通过间接免疫过氧化物酶技术在 6 种原发性人类肝癌中研究了两种细胞外基质和基底膜成分：纤连蛋白 (Fn) 和层粘连蛋白。在具有小梁和管状模式的高分化肝细胞癌中检测到 Fn 和层粘连蛋白的相似分布。两个中度分化的肝癌仅含有Fn。一种低分化肝癌的实质中不存在 Fn 和层粘连蛋白。在3例胆管癌中，层粘连蛋白围绕肿瘤导管，而Fn主要出现在反应性结缔组织基质中。胆管癌合成层粘连蛋白，而不是 Fn，而分化型肝细胞癌在体内同时产生 Fn 和层粘连蛋白。即使在中等分化类型的肝癌中，Fn 的存在也与其他器官发生的癌症的发现相反，它可以作为原发性肝细胞癌鉴别诊断的标志物。
Two extracellular matrix and basement-membrane components, fibronectin (Fn) and laminin, were studied by the indirect immunoperoxidase technique in 6 primary human liver cancers. Similar distributions of both Fn and laminin were detected in the well differentiated hepatocellular carciomas with trabecular and tubular pattern. Two moderately differentiated hepatomas contained Fn only. Neither Fn nor laminin were present in the parenchyma of one poorly differentiated hepatoma. In 3 cases of cholangiocarcinoma, laminin surrounded the tumorous ducts, while Fn appeared mainly in the reactive connective tissue stroma. Bile-duct cancers synthetize laminin, and not Fn while differentiated hepatocellular carcinomas produce both Fn and laminin in vivo. The presence of Fn even in moderately differentiated types of liver cancer is in contrast to the findings for carcinomas developing from other organs and it may serve as a marker for primary hepatocellular carinomas in the differential diagnosis.