Progressive Transformation of Hippocampal Neuronal Representations in "Morphed" Environments
Progressive Transformation of Hippocampal Neuronal Representations in "Morphed" Environments
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DOI：
10.1016/j.neuron.2005.09.007
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发表时间：
2005-10-20
期刊：
影响因子：
16.2
通讯作者：
Moser, EI
中科院分区：
文献类型：
--
作者：
Leutgeb, JK;Leutgeb, S;Moser, EI
不同熟悉环境的海马体神经编码被认为反映了不同的吸引状态，可能在循环CA3网络中实现。吸引子网络的一个定义性质是，当网络的输入发生变化时，它能够在预先建立的（学习的）表示之间进行尖锐和连贯的转换。为了确定海马体神经元集合是否表现出这种不连续性，我们在CA3和CA1中记录了当一个熟悉的方形记录框以可量化的步骤变成一个熟悉的圆形记录框时，同时保持其他输入不变。我们观察到从初始到最终的网络状态是一个渐进的非相干过程。在CA3中，变换伴随着明显的滞后，导致与仅呈现方形和圆形时相比，末端状态更加相似。这些观察结果表明，海马体细胞组合能够增加塑性变形，不协调的信息被纳入预先存在的表征。
Hippocampal neural codes for different, familiar environments are thought to reflect distinct attractor states, possibly implemented in the recurrent CA3 network. A defining property of an attractor network is its ability to undergo sharp and coherent transitions between pre-established (learned) representations when the inputs to the network are changed. To determine whether hippocampal neuronal ensembles exhibit such discontinuities, we recorded in CA3 and CA1 when a familiar square recording enclosure was morphed in quantifiable steps into a familiar circular enclosure while leaving other inputs constant. We observed a gradual noncoherent progression from the initial to the final network state. In CA3, the transformation was accompanied by significant hysteresis, resulting in more similar end states than when only square and circle were presented. These observations suggest that hippocampal cell assemblies are capable of incremental plastic deformation, with incongruous information being incorporated into pre-existing representations.