Failure of GnRH agonist-triggered oocyte maturation: its cause and management
Failure of GnRH agonist-triggered oocyte maturation: its cause and management
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DOI：
10.1007/s10815-013-9966-4
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发表时间：
2013-04-01
影响因子：
3.1
通讯作者：
Endo, Toshiaki
中科院分区：
文献类型：
--
作者：
Asada, Yoshimasa;Itoi, Fumiaki;Endo, Toshiaki
在本研究中，我们调查了 GnRHa 未能触发卵母细胞成熟的原因，并提出了发生失败时使用的有效挽救方案。病例报告。一家体外受精 (IVF) 中心。GnRH 激动剂 (GnRHa) 触发卵母细胞成熟失败的 8 例，尽管 LH-RH 测试反应较弱，但 GnRHa 成功触发卵母细胞成熟 1 例。所有病例均通过重新触发成功挽救使用 HCG 成熟，八名患者中的七名实现了持续妊娠并成功分娩。在三名患者中，卵母细胞成熟失败的原因可能是下丘脑-垂体轴暂时或持续严重下调，其他五名患者的原因未知。在 GnRHa 未能触发卵母细胞成熟的情况下，需要用 HCG 重新触发的救援方案可以产生成功的结果。
In the present study we investigated the cause of GnRHa's failure to trigger oocyte maturation and present an effective rescue protocol for use when failure occurs.Case reports.One in vitro fertilization (IVF) center.Eight cases of failure of GnRH agonist (GnRHa)-triggered oocyte maturation and one case of GnRHa successfully triggered oocyte maturation, despite a weak response in the LH-RH test.All cases were successfully rescued by re-triggering maturation using HCG, with seven of the eight patients achieving ongoing pregnancy and successful delivery.In three patients the cause of the oocyte maturation failure was likely temporal or continuous severe down-regulation of the hypothalamus-pituitary-axis, the cause was unknown in the other five patients.In cases where GnRHa fails to trigger oocyte maturation, a rescue protocol entailing re-triggering with HCG can produce successful outcomes.