Malonate produces striatal lesions by indirect NMDA receptor activation.
Malonate produces striatal lesions by indirect NMDA receptor activation.
复制标题
丙二酸通过间接 NMDA 受体激活产生纹状体损伤。
DOI：
10.1016/0006-8993(94)91412-5
复制
发表时间：
1994
期刊：
影响因子：
2.9
通讯作者：
Beal,MF
中科院分区：
文献类型：
--
作者：
Henshaw,R;Jenkins,BG;Schulz,JB;Ferrante,RJ;Kowall,NW;Rosen,BR;Beal,MF
We previously showed that local striatal injections of malonate produce age-dependent excitotoxic lesions. In the present study volumetric analysis confirmed that malonate produces age-dependent striatal lesions. Pretreatment with the non-competitive and competitive NMDA receptor antagonists, MK-801 and LY274614, and with lamotrigine resulted in significant protection in 4-month-old animals. In vivo magnetic resonance imaging of lesion area showed a significant correlation of increasing lesion size and lactate production in rats ranging from 1 to 12 months of age. Histological evaluation showed NADPH-diaphorase neurons were spared. The results provide further evidence that a subtle impairment of energy metabolism may play a role in neurodegenerative diseases.
