Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19.
Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19.
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DOI：
10.1016/j.addr.2021.113848
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发表时间：
2021-11
影响因子：
16.1
通讯作者：
Liptrott NJ
中科院分区：
文献类型：
--
作者：
Brain D;Plant-Hately A;Heaton B;Arshad U;David C;Hedrich C;Owen A;Liptrott NJ
SARS-CoV-2的出现和随之而来的全球大流行导致了前所未有的反应，即确定可以限制中到重度新冠肺炎患者观察到的失控炎症的治疗方法。新冠肺炎背后的免疫病理是复杂的，涉及多个系统的激活和相互作用，包括但不限于补体、炎症体、内皮细胞以及天然和获得性免疫细胞，从而导致炎症、凝血和组织损伤的错综复杂的轮廓。到目前为止，治疗方法主要集中在抑制凝血、非靶向免疫抑制和/或细胞因子导向的阻滞剂上。不管最近在单个患者的预后和存活率方面取得的改善，需要针对所涉及的单个系统的改进和集中的方法，以进一步改善预后和福祉。本文综述了目前对新冠肺炎病理生理学中涉及的分子和细胞系统的了解，以及它们对病原体清除和损伤的贡献，然后讨论了涉及免疫调节药物递送系统的可能的治疗方案，并总结了它们之间的复杂相互作用。
The emergence of SARS-CoV-2, and the ensuing global pandemic, has resulted in an unprecedented response to identify therapies that can limit uncontrolled inflammation observed in patients with moderate to severe COVID-19. The immune pathology behind COVID-19 is complex and involves the activation and interaction of multiple systems including, but not limited to, complement, inflammasomes, endothelial as well as innate and adaptive immune cells to bring about a convoluted profile of inflammation, coagulation and tissue damage. To date, therapeutic approaches have focussed on inhibition of coagulation, untargeted immune suppression and/or cytokine-directed blocking agents. Regardless of recently achieved improvements in individual patient outcomes and survival rates, improved and focussed approaches targeting individual systems involved is needed to further improve prognosis and wellbeing. This review summarizes the current understanding of molecular and cellular systems involved in the pathophysiology of COVID-19, and their contribution to pathogen clearance and damage to then discuss possible therapeutic options involving immunomodulatory drug delivery systems as well as summarising the complex interplay between them.
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DOI：
10.1016/j.ijid.2020.11.149
发表时间：
2021-03
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Balkhair A;Al-Zakwani I;Al Busaidi M;Al-Khirbash A;Al Mubaihsi S;BaTaher H;Al Aghbari J;Al Busaidi I;Al Kindi M;Baawain S;Al Alawi A;Al Lawati A;Al Rawahi B;Al-Baimani K;Al Zidi K;Elfatih N;Dawud B;John B;Rehman F;Yousif F;Al Khadouri G;Saber I;Lal J;Gargouri M;Al-Ward M;AbuDraz N;Al Ruqeishi S;Kumar S;Abdelmottaleb W;Al-Naamani Z;Bin Nazar Z;Balkhair O
通讯作者：
Balkhair O
影响因子：
3.7
作者：
Brunaugh AD;Seo H;Warnken Z;Ding L;Seo SH;Smyth HDC
通讯作者：
Smyth HDC
影响因子：
4.6
作者：
Chaccour C;Abizanda G;Irigoyen-Barrio Á;Casellas A;Aldaz A;Martínez-Galán F;Hammann F;Gil AG
通讯作者：
Gil AG
影响因子：
32.4
作者：
Burzynski, Laura C.;Humphry, Melanie;Clarke, Murray C. H.
通讯作者：
Clarke, Murray C. H.
影响因子：
5.2
作者：
AbouAitah, Khaled;Hassan, Heba A.;Lojkowski, Witold
通讯作者：
Lojkowski, Witold