Predictive model of diagnosing probable cases of severe acute respiratory syndrome in febrile patients with exposure risk
Predictive model of diagnosing probable cases of severe acute respiratory syndrome in febrile patients with exposure risk
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DOI：
10.1016/s0196-0644(03)00817-5
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发表时间：
2004-01-01
影响因子：
6.2
通讯作者：
Chen, WJ
中科院分区：
文献类型：
--
作者：
Chen, SY;Su, CP;Chen, WJ
研究目的：自2003年3月12日世界卫生组织发布关于严重急性呼吸综合征（SARS）的全球警报以来，该疾病已成为全球重大的公共卫生挑战。本研究的目的是确定 SARS 的临床危险因素，并开发早期诊断的评分系统。 方法：对所有到急诊室 (ED) 就诊且在家中或急诊室记录的体温高于 38.0(o)C (100.3(o)F) 的患者的详细临床数据，并评估 14 天内接触 SARS 的风险。疑似SARS的诊断是根据疾病预防控制中心的定义进行的。确定 SARS 组和非 SARS 组之间在症状、体征和实验室检查表现上存在显着差异的项目，并用于开发评分系统。 结果：入组了 70 名患者，其中 8 名被诊断为可能患有 SARS。最初出院的患者及其亲属均未患上SARS。与非 SARS 组相比，SARS 组更年轻（33.9+/-15.9 岁 vs 44+/-9.8 岁；P=.02），发烧时间超过 5 天的比例更高（87.5% vs 6.5%；P
Study objective: Since the World Health Organization issued a global alert about severe acute respiratory syndrome (SARS) on March 12, 2003, the illness has become a major public health challenge worldwide. The objective of this study is to identify the clinical risk factors of SARS and to develop a scoring system for early diagnosis.Methods: The detailed clinical data of all patients presenting to the emergency department (ED) with a temperature higher than 38.0(o)C (100.3(o)F) documented at home or at the ED, and risks of exposure to SARS within 14 days were assessed. The diagnosis of probable SARS was made according to the definition of the Centers for Disease Control and Prevention. Items with significant differences among symptoms, signs, and laboratory tests on presentation between SARS and non-SARS groups were determined and used to develop the scoring system.Results: Seventy patients were enrolled and 8 were diagnosed as probably having SARS. None of the initially discharged patients or their relatives developed SARS. Compared with the non-SARS group, the SARS group was younger (33.9+/-15.9 years versus 44+/-9.8 years; P=.02), had a higher percentage of fever prolonged more than 5 days (87.5% versus 6.5%; P