Effects of Prehypertension and Hypertension Subtype on Cardiovascular Disease in the Asia-Pacific Region
Effects of Prehypertension and Hypertension Subtype on Cardiovascular Disease in the Asia-Pacific Region
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DOI：
10.1161/hypertensionaha.111.187252
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发表时间：
2012-06-01
期刊：
影响因子：
8.3
通讯作者：
Woodward, Mark
中科院分区：
文献类型：
--
作者：
Arima, Hisatomi;Murakami, Yoshitaka;Woodward, Mark
国家高血压预防、检测、评估和治疗联合委员会的第七次报告将血压（BP）水平在120至139/80至89 mm Hg之间定义为高血压前期，大于等于140/90 mm Hg的为高血压。高血压可分为3类，单纯舒张压（IDH;收缩压= 90 mmHg），单纯收缩压（收缩压≥ 140 mmHg，舒张压= 140 mmHg，舒张压≥ 90 mmHg）。虽然有明确的证据表明，单纯收缩期高血压和收缩-舒张期高血压增加了未来血管事件的风险，但IDH的影响仍不确定。目的是确定亚太地区高血压前期和高血压亚型（IDH、单纯收缩期高血压和收缩-舒张期高血压）对心血管疾病（CVD）风险的影响。亚太队列研究协作是该地区队列研究的个体参与者数据概述。这项分析包括来自36项队列研究的346570名参与者。结局为致死性和非致死性CVD。采用校正了年龄、胆固醇和吸烟的考克斯比例风险模型，并按性别和研究分层，探讨了BP类别和CVD之间的关系。与正常血压相比，
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure defined blood pressure (BP) levels of 120 to 139/80 to 89 mm Hg as prehypertension and those of >= 140/90 mm Hg as hypertension. Hypertension can be divided into 3 categories, isolated diastolic (IDH; systolic BP = 90 mmHg), isolated systolic (systolic BP >= 140 mm Hg and diastolic BP = 140 mm Hg and diastolic BP >= 90 mmHg). Although there is clear evidence that isolated systolic hypertension and systolic-diastolic hypertension increase the risks of future vascular events, there remains uncertainty about the effects of IDH. The objective was to determine the effects of prehypertension and hypertension subtypes (IDH, isolated systolic hypertension, and systolic-diastolic hypertension) on the risks of cardiovascular disease (CVD) in the Asia-Pacific Region. The Asia Pacific Cohort Studies Collaboration is an individual participant data overview of cohort studies in the region. This analysis included a total of 346570 participants from 36 cohort studies. Outcomes were fatal and nonfatal CVD. The relationship between BP categories and CVD was explored using a Cox proportional hazards model adjusted for age, cholesterol, and smoking and stratified by sex and study. Compared with normal BP (