Guidelines for performing Mendelian randomization investigations: update for summer 2023.
Guidelines for performing Mendelian randomization investigations: update for summer 2023.
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DOI：
10.12688/wellcomeopenres.15555.3
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发表时间：
2019-01-01
影响因子：
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通讯作者：
Theodoratou, Evropi
中科院分区：
文献类型：
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作者：
Burgess, Stephen;Davey Smith, George;Theodoratou, Evropi
本文提供了执行孟德尔随机化调查的指导方针。它的目标是寻求进行分析和撰写他们的发现的实践者，以及寻求评估孟德尔随机化手稿的期刊编辑和评论家。指南分为十个部分：动机和范围、数据来源、遗传变异的选择、变异协调、主要分析、补充分析和敏感性分析（一个部分关于稳健的统计方法，另一个部分关于其他方法）、扩展和附加分析、数据展示和解释。这些指南将根据社区的反馈和该领域的进展进行更新。将根据需要定期更新，至少每24个月更新一次。
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 24 months.