Elimination of Borrelia burgdorferi and Anaplasma phagocytophilum in Rodent Reservoirs and Ixodes scapularis Ticks Using a Doxycycline Hyclate-Laden Bait
Elimination of Borrelia burgdorferi and Anaplasma phagocytophilum in Rodent Reservoirs and Ixodes scapularis Ticks Using a Doxycycline Hyclate-Laden Bait
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DOI：
10.4269/ajtmh.2011.11-0292
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发表时间：
2011-12-01
影响因子：
3.3
通讯作者：
Piesman, Joseph
中科院分区：
文献类型：
--
作者：
Dolan, Marc C.;Schulze, Terry L.;Piesman, Joseph
在新泽西的莱姆病流行区进行了一项田间试验，以确定盐酸多西环素啮齿动物诱饵对保护和治愈小型哺乳动物宿主以及降低肩突硬蜱对伯氏疏螺旋体和嗜吞噬细胞无浆体的感染率的效力。将载有多西环素的诱饵以500 mg/kg的浓度配制，并在未成熟蜱虫进食季节期间在啮齿动物靶向诱饵盒中递送。对于B，治疗2年后从治疗区恢复的受感染小型哺乳动物的百分比降低了86.9%。burgdorferi和A.嗜吞噬细胞菌两种B在寻找若虫蜱中的感染率。burgdorferi和A.嗜吞噬细胞分别减少94.3%和92%。本研究的结果表明，强力霉素浸渍诱饵是降低B感染率的有效手段。burgdorferi和A.嗜吞噬细胞的啮齿动物水库和questing I。肩胛肌蜱虫
A field trial was conducted in a Lyme disease-endemic area of New Jersey to determine the efficacy of a doxycyline hyclate rodent bait to prophylactically protect and cure small-mammal reservoirs and reduce infection rates in questing Ixodes scapularis ticks for Borrelia burgdorferi and Anaplasma phagocytophilum. The doxycycline-laden bait was formulated at a concentration of 500 mg/kg and delivered during the immature tick feeding season in rodent-targeted bait boxes. The percentage of infected small mammals recovered from treated areas after 2 years of treatment was reduced by 86.9% for B. burgdorferi and 74% for A. phagocytophilum. Infection rates in questing nymphal ticks for both B. burgdorferi and A. phagocytophilum were reduced by 94.3% and 92%, respectively. Results from this study indicate that doxycycline-impregnated bait is an effective means of reducing infection rates for B. burgdorferi and A. phagocytophilum in both rodent reservoirs and questing I. scapularis ticks.