B-cell lymphopoiesis in mouse and man.

B-cell lymphopoiesis in mouse and man.
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小鼠和人的 B 细胞淋巴细胞生成。

DOI:
10.1016/s0952-7915(98)80248-3
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发表时间:
1998
影响因子:
7
通讯作者:
LeBien,TW
LeBien,TW
中科院分区:
医学2区
文献类型:
--
作者:
LeBien,TW

文献摘要

被引文献

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功能性免疫球蛋白基因重排是哺乳动物骨髓中B细胞发育成功的必要条件,但其他因素也很重要。过去一年中报道的研究为影响B细胞前体命运的表面受体复合体和信号转导结果提供了新的见解。分泌的和膜相关的基质细胞产物的鉴定和特征,以及它们对B细胞前体的作用,是目前正在进行的研究的一个平行领域。
Functional immunoglobulin gene rearrangement is a sine qua non for successful B cell development in mammalian bone marrow, but other factors are also important. Studies reported during the past year have contributed new insight into the surface receptor complexes and signaling outcomes that influence the fate of B cell precursors. Identification and characterization of secreted and membrane-associated stromal cell products, and their actions on B-cell precursors, was a parallel area of ongoing investigation.