Histologic effects of collagen-filled interlocking detachable coils in the ablation of experimental aneurysms in swine.
Histologic effects of collagen-filled interlocking detachable coils in the ablation of experimental aneurysms in swine.
复制标题
胶原填充的互锁可拆卸弹簧圈在猪实验性动脉瘤消融中的组织学效应。
DOI：
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复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
G. Bonner
中科院分区：
文献类型：
--
作者：
R. Dawson;G. Shengelaia;A. Krisht;G. Bonner
目的
旨在评估具有交联牛胶原蛋白内核的铂微弹簧圈在实验诱导的猪动脉瘤中产生的组织学变化，并评估该系统输送胶原蛋白的可行性。
方法
在7只猪舍猪的颈总动脉侧壁上建立双侧囊状动脉瘤。8个动脉瘤用设计有互锁解脱机制的弹簧圈治疗：其中4个弹簧圈有胶原蛋白内核;另外4个，铂微弹簧圈有类似的设计，但没有胶原蛋白芯轴。两种类型弹簧圈在动脉瘤内的填充密度大致相同。其他6个动脉瘤未接受治疗，作为对照。在治疗时（动脉瘤形成后2周）和治疗后1、4和8周获得血管造影片。所有动物在治疗后8周（形成动脉瘤后10周）处死。将动脉和动脉瘤整块切除并固定用于组织病理学研究。
结果
联锁分离机制工作良好。两种类型弹簧圈在实现动脉瘤完全血栓形成方面几乎没有差异（胶原芯弹簧圈治疗的4个动脉瘤中有3个，传统弹簧圈治疗的4个动脉瘤中有2个）。胶原芯线圈刺激线圈近端区域新胶原形成，胶原芯线圈附近的成纤维细胞比传统线圈附近的成纤维细胞更多。
结论
在该实验模型中，通过包埋在微线圈中的异源交联胶原刺激局部成纤维细胞增殖和胶原产生。这种生物刺激有望提高人类动脉瘤的血管内治愈率。
PURPOSE
To assess the histologic changes produced by platinum microcoils with an inner core of cross-linked bovine collagen in experimentally induced aneurysms in swine, and to assess the feasibility of the system for the delivery of the collagen.
METHODS
Bilateral pouch aneurysms were created in the side wall of the common carotid artery in seven barnyard pigs. Eight aneurysms were treated with coils designed with an interlocking detachment mechanism: in four of these, the coils had an inner core of collagen; in the other four, the platinum microcoils had a similar design but without the collagen mandrel. The packing density of the coils within the aneurysm was approximately the same for both types of coils. The other six aneurysms were left untreated and served as controls. Angiograms were obtained at the time of treatment (2 weeks after the aneurysms were created) and at 1, 4, and 8 weeks after treatment. All animals were killed 8 weeks after the treatment (10 weeks after the aneurysms were created). Arteries and aneurysms were resected en bloc and fixed for histopathologic study.
RESULTS
The interlocking detachment mechanism worked well. Little difference was noted between the two types of coils in their ability to effect complete aneurysmal thrombosis (three of four aneurysms treated with collagen-core coils and two of four aneurysms treated with conventional coils). The collagen-core coils stimulated new collagen formation in areas proximal to the coils, and more fibroblasts were noted near the collagen-core coils than near the conventional coils.
CONCLUSION
Local fibroblast proliferation and collagen production were stimulated by heterologous cross-linked collagen embedded in micro-coils in this experimental model. Such biologic stimulation holds promise for improving the endovascular cure rate of aneurysms in humans.
影响因子：
4.1
作者：
GUGLIELMI, G;VINUELA, F;SEPETKA, I
通讯作者：
SEPETKA, I
电可脱线圈颅内动脉瘤的血管内闭塞：动脉瘤颈大小与治疗结果的相关性。
DOI：
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发表时间：
1994
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
FernandezZubillaga,A;Guglielmi,G;Viñuela,F;Duckwiler,GR
通讯作者：
Duckwiler,GR