New insights into the regulatory roles of glutathione in NLRP3-inflammasome-mediated immune and inflammatory responses
New insights into the regulatory roles of glutathione in NLRP3-inflammasome-mediated immune and inflammatory responses
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关于谷胱甘肽在 NLRP3 炎症小体介导的免疫和炎症反应中的调节作用的新见解
DOI：
10.1093/jb/mvab158
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Sawa Tomohiro
中科院分区：
文献类型：
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作者：
Zhang Tianli;Tsutsuki Hiroyasu;Li Xiaoyan;Sawa Tomohiro
谷胱甘肽（GSH）是哺乳动物细胞中含量最丰富的非蛋白巯基（-SH）。其合成和代谢用于维持细胞还原-氧化（氧化还原）稳态，这对于包括增殖、分化和死亡的多个细胞过程是重要的。越来越多的证据表明，GSH的重要作用远远超出了其氧化剂和亲电体清除活性和调节细胞寿命的作用。最近的研究结果表明，GSH水平的改变与广泛的病理学密切相关，包括细菌和病毒感染，神经退行性疾病和自身免疫性疾病，所有这些疾病的特征还在于含有NLR家族pyrin结构域3（NLRP 3）炎性体的异常激活。作为这些发现的结果，GSH在影响NLRP 3炎性体的活化中被指定为中心作用。为了扩展我们最近在理解这一过程方面的进展，我们在这里讨论了GSH在NLRP 3炎性小体激活中的新作用，以及GSH在相关病理学中的治疗潜力。
Glutathione (GSH) is the most abundant non-protein thiol (-SH) in mammalian cells. Its synthesis and metabolism serve to maintain cellular reduction–oxidation (redox) homeostasis, which is important for multiple cellular processes including proliferation, differentiation and death. An accumulating body of evidence suggests that the essential roles of GSH extended far beyond its oxidant and electrophile scavenger activities and regulatory role in the lifespan of cells. Recent findings revealed that altered GSH levels are closely associated with a wide range of pathologies including bacterial and viral infections, neurodegenerative diseases and autoimmune disorders, all of which are also characterized by aberrant activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome. As a result of these findings, GSH was assigned a central role in influencing the activation of the NLRP3 inflammasome. To expand on our recent advances in understanding this process, we discuss here the emerging roles of GSH in activation of the NLRP3 inflammasome, and the therapeutic potential of GSH in its associated pathologies.