Promoter clearance by RNA polymerase II.
Promoter clearance by RNA polymerase II.
复制标题
RNA 聚合酶 II 清除启动子。
DOI：
10.1016/j.bbagrm.2012.08.010
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Luse,DonalS
中科院分区：
文献类型：
--
作者：
Luse,DonalS
当 RNA 聚合酶 II (pol II) 转录复合物从起始阶段转变为转录物延伸阶段时，必须发生许多变化。在转录的中间阶段，与起始因子的接触消失，并与新生转录物建立稳定的关联。这些变化共同构成启动子清除。一旦转录物延伸复合物达到其特性与具有更长转录物的复合物的特性无法区分的程度，启动子清除就完成了。 pol II 的清除过程由许多步骤组成，并且它在转录起始下游延伸了令人惊讶的长距离。本文是题为“RNA 聚合酶 II 转录本延伸”特刊的一部分。
Many changes must occur to the RNA polymerase II (pol II) transcription complex as it makes the transition from initiation into transcript elongation. During this intermediate phase of transcription, contact with initiation factors is lost and stable association with the nascent transcript is established. These changes collectively comprise promoter clearance. Once the transcript elongation complex has reached a point where its properties are indistinguishable from those of complexes with much longer transcripts, promoter clearance is complete. The clearance process for pol II consists of a number of steps and it extends for a surprisingly long distance downstream of transcription start. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.