Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design.
Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design.
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DOI：
10.4049/jimmunol.181.5.3039
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发表时间：
2008-09-01
期刊：
影响因子：
--
通讯作者：
Sant AJ
中科院分区：
文献类型：
--
作者：
Weaver JM;Lazarski CA;Richards KA;Chaves FA;Jenks SA;Menges PR;Sant AJ
Immunodominance refers to the restricted peptide specificity of T cells that are detectable after an adaptive immune response. For CD4 T cells, many of the mechanisms used to explain this selectivity suggest that events related to antigen processing play a major role in determining a peptide’s ability to recruit CD4 T cells. Implicit in these models is the prediction that the molecular context in which an antigenic peptide is contained will impact significantly on its immunodominance. Here, we present evidence that the selectivity of CD4 T cell responses to peptides contained within protein antigens is not detectably influenced by the location of the peptide in a given protein or the primary sequence of the protein that bears the test peptide. We have used molecular approaches to change the location of peptides within complex protein antigens and to change the flanking sequences that border the peptide epitope to now include a protease site and find that immunodominance or crypticity of a peptide observed in its native protein context is preserved. Collectively, these results suggest immunodominance of peptides contained in complex antigens is due to an intrinsic factor of the peptide, based upon the affinity of that peptide for MHC class II molecules. These findings are discussed with regard to implications for vaccine design.
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