Need for Speed: The Importance of Physiological Strain Rates in Determining Myocardial Stiffness.
Need for Speed: The Importance of Physiological Strain Rates in Determining Myocardial Stiffness.
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DOI：
10.3389/fphys.2021.696694
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发表时间：
2021
影响因子：
4
通讯作者：
Prosser BL
中科院分区：
文献类型：
--
作者：
Caporizzo MA;Prosser BL
心脏是粘弹性的，这意味着它的顺应性与它伸展的速度成反比。在舒张期充盈期间，左心室以粘弹性力影响心室顺应性的速率快速扩张。在心脏病中，心肌粘弹性通常增加，并可直接阻碍舒张期充盈以减少心输出量。因此，降低心肌粘弹性的治疗可为心力衰竭提供益处，特别是对于舒张性心力衰竭患者。然而，许多实验技术不能或不表征心肌粘弹性，我们对粘弹性的分子调节剂及其对心脏性能的影响缺乏了解。这在很大程度上可能源于对技术的依赖，这些技术要么不询问粘弹性（即，使用非生理应变率）或损害有助于粘弹性的元件的技术（即，损害细胞骨架完整性的去皮或透化的肌肉制品）。临床上，心脏粘弹性表征具有挑战性，需要在有创血流动力学过程中增加应变率调制。尽管存在这些挑战，但数据继续显示粘弹性对心脏生理学和病理学的有意义的贡献，因此表征粘弹性的创新方法有助于阐明心肌力学的基本特性并促进新治疗策略的开发。
The heart is viscoelastic, meaning its compliance is inversely proportional to the speed at which it stretches. During diastolic filling, the left ventricle rapidly expands at rates where viscoelastic forces impact ventricular compliance. In heart disease, myocardial viscoelasticity is often increased and can directly impede diastolic filling to reduce cardiac output. Thus, treatments that reduce myocardial viscoelasticity may provide benefit in heart failure, particularly for patients with diastolic heart failure. Yet, many experimental techniques either cannot or do not characterize myocardial viscoelasticity, and our understanding of the molecular regulators of viscoelasticity and its impact on cardiac performance is lacking. Much of this may stem from a reliance on techniques that either do not interrogate viscoelasticity (i.e., use non-physiological rates of strain) or techniques that compromise elements that contribute to viscoelasticity (i.e., skinned or permeabilized muscle preparations that compromise cytoskeletal integrity). Clinically, cardiac viscoelastic characterization is challenging, requiring the addition of strain-rate modulation during invasive hemodynamics. Despite these challenges, data continues to emerge demonstrating a meaningful contribution of viscoelasticity to cardiac physiology and pathology, and thus innovative approaches to characterize viscoelasticity stand to illuminate fundamental properties of myocardial mechanics and facilitate the development of novel therapeutic strategies.
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影响因子：
2.1
作者：
Falcao-Pires, I.;Fontes-Sousa, A. P.;Leite-Moreira, A. F.
通讯作者：
Leite-Moreira, A. F.
影响因子：
120.7
作者：
Gulati, Ankur;Jabbour, Andrew;Prasad, Sanjay K.
通讯作者：
Prasad, Sanjay K.
TITIN的磷酸化可调节心脏肌肉的被动刚度，依赖性替丁同工型。
影响因子：
3.8
作者：
Fukuda, Norio;Wu, Yiming;Nair, Preetha;Granzier, Henk L
通讯作者：
Granzier, Henk L
影响因子：
5.5
作者：
DETOMBE, PP;TERKEURS, HEDJ
通讯作者：
TERKEURS, HEDJ
影响因子：
4
作者：
Herwig, Melissa;Kolijn, Detmar;Hamdani, Nazha
通讯作者：
Hamdani, Nazha