CORRELATION OF SERUM INTERLEUKIN-6 LEVELS WITH JOINT INVOLVEMENT AND THROMBOCYTOSIS IN SYSTEMIC JUVENILE RHEUMATOID-ARTHRITIS
CORRELATION OF SERUM INTERLEUKIN-6 LEVELS WITH JOINT INVOLVEMENT AND THROMBOCYTOSIS IN SYSTEMIC JUVENILE RHEUMATOID-ARTHRITIS
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DOI：
10.1002/art.1780340912
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发表时间：
1991-09-01
影响因子：
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通讯作者：
MARTINI, A
中科院分区：
文献类型：
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作者：
DEBENEDETTI, F;MASSA, M;MARTINI, A
我们使用杂交瘤细胞系B9检测了25例全身性幼年类风湿性关节炎（JRA）患者70份血清样本中的白细胞介素-6 （IL-6）水平。全身性JRA患者在活动性疾病期间血清IL-6水平显著升高（平均+/- SD 92.1 +/- 75.1杂交瘤生长因子单位/ml；与健康年龄匹配的对照组相比，P < 0.00001），但在缓解期无显著升高。血清IL-6水平与关节受累程度和严重程度相关（P < 0.001），与血小板计数相关（P < 0.05）。我们的数据表明IL-6在全身性JRA的发病机制中起着重要作用。
We measured interleukin-6 (IL-6) levels in 70 serum samples obtained from 25 patients with systemic-onset juvenile rheumatoid arthritis (JRA), using the hybridoma cell line B9. Patients with systemic-onset JRA had significantly elevated serum IL-6 levels during active disease (mean +/- SD 92.1 +/- 75.1 hybridoma growth factor units/ml; P < 0.00001 versus healthy age-matched controls), but not during remission. Serum IL-6 levels correlated with the extent and severity of joint involvement (P < 0.001) and with platelet counts (P < 0.05). Our data suggest that IL-6 plays a significant role in the pathogenesis of systemic-onset JRA.