Evaluation of acoustic radiation force impulse imaging for determination of liver stiffness using transient elastography as a reference
Evaluation of acoustic radiation force impulse imaging for determination of liver stiffness using transient elastography as a reference
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DOI：
10.3748/wjg.v18.i10.1077
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发表时间：
2012-03-14
影响因子：
4.3
通讯作者：
Haeussinger, Dieter
中科院分区：
文献类型：
--
作者：
Kircheis, Gerald;Sagir, Abdurrahman;Haeussinger, Dieter
目的：以瞬态弹性成像[FibroScan（c）（FS）]作为参考，评价声辐射力脉冲成像（ARFI）的截止值和性能。所有患者均接受FS（FS-LS）和ARFI（剪切波速度定量; ARFI-SWV）肝脏硬度测量，并确定ARFI与FS相比的性能。结果：ARFI检测肝硬度的成功率明显高于FS [604/606（99.7%）vs 482/606（79.5%），P < 0.001]。ARFI-SWV与FS-LS显著相关（r = 0.920，P < 0.001）。ARFI-SWV随纤维化分期显著增加（无显著纤维化患者（FS-LS < 7.6 kPa）为1.09 +/- 0.13 m/s;显著肝纤维化患者（FS-LS < 7.6 kPa）为1.46 +/- 0.27 m/s）。确定了无显著纤维化（1.29 m/s;灵敏度91.4%和特异性92.6%）和肝硬化（1.60 m/s;灵敏度92.3%和特异性96.5%）的ARFI-SWV截止值。对于接受肝活检的患者，预测肝纤维化（F >= 2）的最佳截止值为1.32 m/s（敏感性87.0%，特异性80.0%），肝硬化（F4）为1.62 m/s（敏感性100%，特异性85.7%）。一个很好的观察者间和观察者内的重复性观察ARFI-SWV determination.CONCLUSION：ARFI-SWV的截止值为1.29米/秒似乎是最佳的患者没有显着的肝纤维化和1.60米/秒的肝硬化患者。(c)2012年百世登。All rights reserved.
AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan (c) (FS)] as a reference.METHODS: Six hundred and six patients were enrolled in this study. All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined. Sixty-eight patients underwent liver biopsy.RESULTS: Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7%) vs 482/606 (79.5%), P < 0.001]. ARFI-SWV correlated significantly with FS-LS (r = 0.920, P < 0.001). ARFI-SWV increased significantly with the stage of fibrosis (1.09 +/- 0.13 m/s for patients with no significant fibrosis (FS-LS < 7.6 kPa); 1.46 +/- 0.27 m/s for patients with significant liver fibrosis (7.6 < FS-LS 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m/s; sensitivity 92.3% and specificity 96.5%). The optimal cut-off value for predicting liver fibrosis (F >= 2) was 1.32 m/s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations.CONCLUSION: An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis. (c) 2012 Baishideng. All rights reserved.