Clinical utility of 30% relative decline in MRI-PDFF in predicting fibrosis regression in non-alcoholic fatty liver disease.
Clinical utility of 30% relative decline in MRI-PDFF in predicting fibrosis regression in non-alcoholic fatty liver disease.
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DOI：
10.1136/gutjnl-2021-324264
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发表时间：
2022-05
期刊：
影响因子：
24.5
通讯作者：
Loomba R
中科院分区：
文献类型：
--
作者：
Tamaki N;Munaganuru N;Jung J;Yonan AQ;Loomba RR;Bettencourt R;Ajmera V;Valasek MA;Behling C;Sirlin CB;Loomba R
新出现的数据表明，磁共振成像-质子密度脂肪分数(MRI-PDFF)评估的肝脏脂肪相对下降30%可能与非酒精性脂肪性肝病(NAFLD)活动评分的改善有关，但MRI-PDFF下降与纤维化消退之间的关联尚不清楚。因此，我们的目标是研究≥相对下降30%与非酒精性脂肪肝纤维化消退之间的关系。这项前瞻性研究包括100名经活检证实的NAFLD患者，他们在两个时间点进行了成对的同期MRI-PDFF评估。MRI-PDFF值定义为≥相对下降30%。主要结果为≥-1期组织学纤维化消退。年龄中位数为54岁(43-62岁)，体重指数为31.9(29-36)kg/m2。在多变量调整的Logistic回归分析中(调整了年龄、性别、糖尿病状况、种族/民族、活检间隔、γ-谷氨酰转移酶、磁共振弹性成像的肝脏硬度和血小板计数的变化)，MRI-PDFF反应是纤维化回归的独立预测因素，调整后的优势比为6.46(95%可信区间：1.1-37.0，p=0.04)。MRI-PDFF反应伴纤维化消退、纤维化无变化和纤维化进展的患者比例分别为40.0%、24.6%和13.0%，且随着纤维化消退而增加(p=0.03)。在早期试验中，≥的≥-PDF值减少30%，可以提供一个有用的估计纤维化中MIP-PDF1期改善的几率。这些数据可能有助于估计非酒精性脂肪性肝炎试验的样本量。
Emerging data suggest that a 30% relative decline in liver fat as assessed by magnetic resonance imaging-proton density fat fraction (MRI-PDFF) may be associated with Nonalcoholic fatty liver disease (NAFLD) Activity Score improvement, but the association between decline in MRI-PDFF and fibrosis regression is not known. Therefore, we aimed to examine the association between ≥ 30% relative decline in MRI-PDFF and fibrosis regression in NAFLD. This prospective study included 100 well-characterized patients with biopsy-proven NAFLD with paired contemporaneous MRI-PDFF assessment at two time points. MRI-PDFF response was defined as ≥ 30% relative decline in MRI-PDFF. The primary outcome was ≥1 stage histological fibrosis regression. The median (interquartile range) age was 54 (43-62) years, and body mass index was 31.9 (29-36) kg/m2. In multivariable-adjusted logistic regression analysis (adjusted for age, gender, diabetes status, race/ethnicity, interval between biopsies, gamma-glutamyl transferase, liver stiffness by magnetic resonance elastography, and change in platelet counts), MRI-PDFF response was an independent predictor of fibrosis regression with adjusted odds ratio of 6.46 (95% confidence interval: 1.1-37.0, p = 0.04). The proportion of patients with MRI-PDFF response with fibrosis regression, fibrosis no change, and fibrosis progression were 40.0%, 24.6%, and 13.0%, respectively, and the proportion of patients with MRI-PDFF response increased with fibrosis regression (p = 0.03). ≥ 30% reduction in MRI-PDFF in early phase trials can provide a useful estimate of odds of ≥ 1 stage improvement in fibrosis. These data may be helpful in sample-size estimation in nonalcoholic steatohepatitis trials.
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DOI：
10.1002/hep.26455
发表时间：
2013-12
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Noureddin M;Lam J;Peterson MR;Middleton M;Hamilton G;Le TA;Bettencourt R;Changchien C;Brenner DA;Sirlin C;Loomba R
通讯作者：
Loomba R
肝脏中的弹性。
影响因子：
4
作者：
Kanta J
通讯作者：
Kanta J
对医疗统计信息的自由使用的易于使用的软件“ EZR”的调查。
影响因子：
4.8
作者：
Kanda Y
通讯作者：
Kanda Y
DOI：
10.1002/hep.29797
发表时间：
2018-08
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Caussy C;Reeder SB;Sirlin CB;Loomba R
通讯作者：
Loomba R
DOI：
10.1002/hep.29477
发表时间：
2018-05
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Friedman SL;Ratziu V;Harrison SA;Abdelmalek MF;Aithal GP;Caballeria J;Francque S;Farrell G;Kowdley KV;Craxi A;Simon K;Fischer L;Melchor-Khan L;Vest J;Wiens BL;Vig P;Seyedkazemi S;Goodman Z;Wong VW;Loomba R;Tacke F;Sanyal A;Lefebvre E
通讯作者：
Lefebvre E