Lingering Dynamics in Microvascular Blood Flow
Lingering Dynamics in Microvascular Blood Flow
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DOI：
10.1016/j.bpj.2020.12.012
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发表时间：
2021-02-02
影响因子：
3.4
通讯作者：
Wagner, Christian
中科院分区：
文献类型：
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作者：
Kihm, Alexander;Quint, Stephan;Wagner, Christian
脊椎动物体内的微血管网络由最小的血管组成，例如小动脉、毛细血管和小静脉。红细胞 (RBC) 通过这些网络的流动确保了气体交换以及营养物质向组织的运输。血流的任何改变都可能对健康状况产生严重影响。由于这些网络中的血管遵循与红细胞直径相似的尺寸，因此细胞尺度的动态效应起着关键作用。红细胞数值模拟的稳步进展，即使在复杂的网络中，也带来了血流动力学领域的新发现，特别是关于当细胞遇到网络分支时残留事件的影响和动力学。然而，这些结果尚未与体内持续实验的详细分析相匹配。为了量化体内实验中的这种挥之不去的影响，本研究通过活体显微镜和植入的背侧皮褶室分析了叙利亚金仓鼠微脉管系统中的分支血管。它还详细分析了分叉血管顶端细胞的这些挥之不去的影响，影响分支中血流血浆区的时间分布，甚至在严重的情况下导致部分阻塞。
The microvascular networks in the body of vertebrates consist of the smallest vessels such as arterioles, capillaries, and venules. The flow of red blood cells (RBCs) through these networks ensures the gas exchange in as well as the transport of nutrients to the tissues. Any alterations in this blood flow may have severe implications on the health state. Because the vessels in these networks obey dimensions similar to the diameter of RBCs, dynamic effects on the cellular scale play a key role. The steady progression in the numerical modeling of RBCs, even in complex networks, has led to novel findings in the field of hemodynamics, especially concerning the impact and the dynamics of lingering events when a cell meets a branch of the network. However, these results are yet to be matched by a detailed analysis of the lingering experiments in vivo. To quantify this lingering effect in in vivo experiments, this study analyzes branching vessels in the microvasculature of Syrian golden hamsters via intravital microscopy and the use of an implanted dorsal skinfold chamber. It also presents a detailed analysis of these lingering effects of cells at the apex of bifurcating vessels, affecting the temporal distribution of plasmatic zones of blood flow in the branches and even causing a partial blockage in severe cases.