Subjective xerostomia in long-term surviving children and adolescents after pediatric bone marrow transplantation.
Subjective xerostomia in long-term surviving children and adolescents after pediatric bone marrow transplantation.
复制标题
儿童骨髓移植后长期存活儿童和青少年的主观口干症。
作者：
M. Bågesund;J. Winiarski;G. Dahllöf
背景
本研究的目的是评估长期存活的儿童骨髓移植（BMT）患者的口干主观症状是否与低非刺激性唾液分泌率（苏联）和刺激性全唾液分泌率（SSSR）相关。
方法
纳入了53例儿童异基因BMT后生存≥ 2年的患者。估计了前一年以来的苏联、SSSR和唾液分泌率的变化。回答了关于口干症主观症状的问卷。
结果
平均USSR和SSSR分别为0.24+/-0.17和0.90 +/-0.58 ml/min。35%的患者存在唾液腺功能障碍，定义为USSR ≤ 0.1 ml/min或SSSR ≤ 0.5 ml/min。79%的患者表达了一种或多种口干症状，49%的患者给出了至少两个表明口干的答案。随着年龄的增长，主诉次数增多（P<0.05）。USSR（P<0.01）和SSSR（P<0.01）均与口干总主诉数呈负相关。与前一年相比，SSSR减少与两个或两个以上的口干症投诉相关（P<0.01）。夜间或醒来时出现口干是低苏联（P<0.01）和SSSR（P<0.001）的指示。白天报告干燥的患者SSSR显著降低（P<0.05）。
结论
长期存活的儿童BMT患者口干症的主观主诉与唾液腺功能障碍和年龄相关。对这些唾液腺功能障碍的患者进行识别，对缓解其症状和预防继发并发症非常重要。
BACKGROUND
The aim of the present investigation was to evaluate whether the subjective symptoms of dry mouth in long-term-surviving pediatric bone marrow transplant (BMT) patients are associated with low unstimulated salivary secretion rates (USSR) and with stimulated whole salivary secretion rates (SSSR).
METHODS
Fifty-three patients surviving > or =2 years after pediatric allogeneic BMT were included. USSR, SSSR, and the change in salivary secretion rates since the previous year were estimated. A questionnaire regarding subjective symptoms of xerostomia was answered.
RESULTS
The mean USSR and SSSR were 0.24+/-0.17 and 0.90 +/- 0.58 ml/min, respectively. Salivary gland dysfunction, defined as USSR < or =0.1 ml/min or SSSR < or =0.5 ml/min, was present in 35% of the patients. Seventy-nine percent of the patients expressed one or more symptom of dry mouth, and 49% gave at least two answers indicating dry mouth. The number of complaints increased with age at examination (P<0.05). Both USSR (P<0.01) and SSSR (P<0.01) were inversely correlated to the total number of complaints of xerostomia. A reduction in SSSR compared with the year before was correlated to two or more complaints of xerostomia (P<0.01). The presence of dry mouth at night or on awakening was indicative of both low USSR (P<0.01) and SSSR (P<0.001). Patients reporting dryness during the day had significantly lower SSSR (P<0.05).
CONCLUSION
The expression of subjective complaints of xerostomia among long-term surviving pediatric BMT patients is correlated to salivary gland dysfunction and age. It is very important to identify these patients with salivary gland dysfunction to relieve their symptoms and prevent secondary complications.
影响因子：
20.3
作者：
Sanders,JE;Pritchard,S;Mahoney,P;Amos,D;Buckner,CD;Witherspoon,RP;Deeg,HJ;Doney,KC;Sullivan,KM;Appelbaum,FR
通讯作者：
Appelbaum,FR