A multifaceted phosphate tether: application to the C15-C30 subunit of dolabelides A-D.
A multifaceted phosphate tether: application to the C15-C30 subunit of dolabelides A-D.
复制标题
多面磷酸酯链：应用于多拉贝利 A-D 的 C15-C30 亚基。
DOI：
10.1021/ol8001865
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发表时间：
2008
期刊：
影响因子：
5.2
通讯作者：
Hanson,PaulR
中科院分区：
文献类型：
--
作者：
Whitehead,Alan;Waetzig,JoshuaD;Thomas,ChristopherD;Hanson,PaulR
Construction of the C15−C30 subunit of dolabelide utilizing a temporary phosphate tether is described. Two routes are reported that make use of the orthogonal protecting- and leaving-group properties innate to phosphate esters. One route relies on a selective terminal oxidation, while a second utilizes a CM/selective hydrogenation sequence. Both routes depend on a highly regio- and diastereoselective cuprate addition to set the requisite stereochemistry at C22.
