MAGNETIC-RESONANCE IMAGING AND SPECTROSCOPY OF THE PERIARTICULAR INFLAMMATORY SOFT-TISSUE CHANGES IN EXPERIMENTAL ARTHRITIS OF THE RAT
MAGNETIC-RESONANCE IMAGING AND SPECTROSCOPY OF THE PERIARTICULAR INFLAMMATORY SOFT-TISSUE CHANGES IN EXPERIMENTAL ARTHRITIS OF THE RAT
复制标题
DOI：
10.1097/00004424-198511000-00009
复制
发表时间：
1985-01-01
影响因子：
6.7
通讯作者：
GENANT, HK
中科院分区：
文献类型：
--
作者：
TERRIER, F;HRICAK, H;GENANT, HK
采用皮内注射弗氏完全佐剂诱导大鼠关节炎。MRI采用0.35T电阻式成像仪。采用自旋回波（SE）技术，TR=0.5和2.0秒，TE=28和56 msec。注射佐剂后不同时间的后肢和膝关节横轴图像。对正常后肢和关节炎后肢进行体外质子谱分析。每个病例都得到了组织学证实。在TR=2.0秒和TE = 56 msec的自旋回波图像上，炎性软组织病变表现为高强度的病灶区域，T1和T2松弛时间长，自旋密度高。与常规x线摄影和体格检查相比，MRI能更频繁地发现早期软组织改变。本研究提示MRI可能对关节炎的早期诊断有价值。
Arthritis was induced in rats by intradermal injection of Freund''s complete adjuvant. MRI was performed with a resistive imager operating at 0.35T. A spin echo (SE) technique with TR=0.5 and 2.0 seconds, TE=28 and 56 msec was used. Transaxial images of hindpaws and knees were obtained at different times after injection of adjuvant. In vitro proton spectroscopy of normal and arthritic hindpaws was also performed. Histologic confirmation was obtained in each case. Inflammatory soft-tissue lesions were seen as focal areas of high intensity on spin echo images obtained with TR=2.0 seconds and TE = 56 msec and were characterized by long T1 and T2 relaxation times and high spin density. In comparison with both conventional radiography and phsyical examination, early soft-tissue changes were detected more frequently by MRI. This study suggests that MRI is likely to be of value for the early diagnosis of arthritis.