Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst.
Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst.
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DOI：
10.1016/j.devcel.2014.06.019
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发表时间：
2014-08-25
影响因子：
11.8
通讯作者：
Manzanares, Miguel
中科院分区：
文献类型：
--
作者：
Rayon, Teresa;Menchero, Sergio;Nieto, Andres;Xenopoulos, Panagiotis;Crespo, Miguel;Cockburn, Katie;Canon, Susana;Sasaki, Hiroshi;Hadjantonakis, Anna-Katerina;Luis de la Pompa, Jose;Rossant, Janet;Manzanares, Miguel
哺乳动物胚胎发生的第一个谱系选择是滋养外胚层和内细胞团之间的选择，滋养外胚层产生胎盘的滋养细胞，内细胞团来自胚胎本身和卵黄囊。在这些谱系建立之前，早期胚胎中细胞的内外定位和关键转录因子的随机表达，然后被分解为谱系限制性表达。推动这一限制的监管输入以及它们与细胞位置的关系在很大程度上是未知的。在这里，我们展示了一个意想不到的作用，Notch信号调节滋养外胚层与TEAD4合作的CDX2的特异性表达。Notch的活性仅限于外部细胞，并能够影响卵裂球的位置分配，介导对滋养外胚层的优先定位。我们的结果表明，植入前阶段的多个信号输入指定了第一个胚胎谱系。
The first lineage choice in mammalian embryogenesis is that between the trophectoderm, which gives rise to the trophoblast of the placenta, and the inner cell mass, from which derive the embryo proper and the yolk sac. The establishment of these lineages is preceded by the inside-versus-outside positioning of cells in the early embryo and stochastic expression of key transcription factors, which is then resolved into lineage-restricted expression. The regulatory inputs that drive this restriction and how they relate to cell position are largely unknown. Here we show an unsuspected role of Notch signaling in regulating trophectoderm-specific expression of Cdx2 in cooperation with TEAD4. Notch activity is restricted to outer cells and is able to influence positional allocation of blastomeres, mediating preferential localization to the trophectoderm. Our results show that multiple signaling inputs at preimplantation stages specify the first embryonic lineages.
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影响因子：
9.2
作者：
Hirate, Yoshikazu;Hirahara, Shino;Inoue, Ken-ichi;Suzuki, Atsushi;Alarcon, Vernadeth B.;Akimoto, Kazunori;Hirai, Takaaki;Hara, Takeshi;Adachi, Makoto;Chida, Kazuhiro;Ohno, Shigeo;Marikawa, Yusuke;Nakao, Kazuki;Shimono, Akihiko;Sasaki, Hiroshi
通讯作者：
Sasaki, Hiroshi
影响因子：
10.5
作者：
Jedrusik, Agnieszka;Parfitt, David-Emlyn;Zernicka-Goetz, Magdalena
通讯作者：
Zernicka-Goetz, Magdalena
影响因子：
64.5
作者：
Niwa, H;Toyooka, T;Rossant, J
通讯作者：
Rossant, J
影响因子：
4.6
作者：
Muench, Juliane;Gonzalez-Rajal, Alvaro;Luis de la Pompa, Jose
通讯作者：
Luis de la Pompa, Jose
影响因子：
2.6
作者：
Nishioka, Noriyuki;Yamamoto, Shinji;Sasaki, Hiroshi
通讯作者：
Sasaki, Hiroshi