Clinicopathological risk factors for local recurrence in oral squamous cell carcinoma
Clinicopathological risk factors for local recurrence in oral squamous cell carcinoma
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DOI：
10.1016/j.ijom.2012.07.011
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发表时间：
2012-10-01
影响因子：
2.4
通讯作者：
Umeda, M.
中科院分区：
文献类型：
--
作者：
Yanamoto, S.;Yamada, S.;Umeda, M.
口腔鳞状细胞癌（OSCC）初次手术后的局部复发一直被认为是一个预后不良的生存率。本研究的目的是评估口腔鳞状细胞癌局部复发的发生率，并确定局部复发的重要危险因素。作者回顾性分析了187例因口腔鳞癌接受根治性手术的患者的记录。本研究的局部复发率为16.0%（30/187例患者）。局部复发组的生存率为33.3%，明显低于无局部复发组的生存率（94.3%）。浸润方式（POI）、新辅助化疗（NAC）和手术切缘状态被确定为影响局部复发的因素。多因素分析显示，NAG和手术切缘状态是独立的危险因素。在许多NAG治疗的患者中，深切缘在闭合部位被切除，这表明NAG可能导致局部复发和不良结局。没有观察到NAG的疗效，这表明口腔癌的标准治疗是单独手术。
Local recurrence of oral squamous cell carcinoma (OSCC) after primary surgery has been considered to be a poor prognostic entity in terms of survival rate. The purpose of this study is to evaluate the incidence of local recurrence and to identify significant risk factors for the local recurrence in OSCC. The authors retrospectively reviewed records for 187 patients who underwent radical surgery for OSCC. The local recurrence rate was 16.0% (30/187 patients) in this study. The survival rate of patients with local recurrence was 33.3%, which was significantly lower than that (94.3%) of patients without local recurrence. Pattern of invasion (POI), neoadjuvant chemotherapy (NAC), and the status of the surgical margin were identified as factors influencing local recurrence. In particular, NAG and the status of the surgical margin were independent risk factors by multivariate analysis. The deep margin was resected at a close site in many NAG-treated patients, suggesting that NAG may lead to local recurrence and poor outcomes. No efficacy of NAG was observed, suggesting that the standard treatment of oral cancers is surgery alone.