Placebo controlled trial of nicotine chewing gum in general practice.
Placebo controlled trial of nicotine chewing gum in general practice.
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一般实践中尼古丁口香糖的安慰剂对照试验。
作者：
K. Jamrozik;G. Fowler;M. Vessey;N. Wald
在一项双盲研究中，最初招募了 2110 名成年吸烟者来研究戒烟建议在一般实践中的效果，其中 429 名在一年后的随访中报告说他们尝试戒烟失败的人被提供了“一种特殊的戒烟口香糖”，要么是尼古丁口香糖，要么是安慰剂口香糖。在 200 名愿意尝试口香糖的人中，101 人被随机分配到尼古丁口香糖，99 人被随机分配到安慰剂口香糖。六个月后，他们进行了一次未经事先通知的家访，接受了采访，并要求他们提供呼吸样本以进行一氧化碳分析。 25 人声称他们已经戒烟，但其中 7 人呼出的一氧化碳浓度表明他们仍在吸烟。在 18 名戒烟得到验证的人中，10 人接受了活性口香糖，8 人接受了安慰剂口香糖，差异并不显着（支持尼古丁口香糖的几率 = 1.25，95% 置信限 0.47-3.31）。尼古丁口香糖的价值（如果有的话）在一般实践中使用时可能相当小。
Of 2110 adult cigarette smokers originally recruited to a study of the effect of antismoking advice in general practice, 429 who reported at follow up after one year that they had tried unsuccessfully to stop smoking were offered "a special antismoking chewing gum," either nicotine gum or a placebo gum, in a double blind study. Of 200 who were willing to try the gum, 101 were randomly allocated to the nicotine gum and 99 to the placebo gum. They were followed up at six months by an unannounced home visit, at which they were interviewed and asked to provide a breath sample for analysis of carbon monoxide. Twenty five claimed that they had stopped smoking, but, of them, seven exhaled levels of carbon monoxide indicative of continued smoking. Of the 18 in whom giving up smoking was validated, 10 had received active gum and eight placebo gum, a difference which was not significant (odds in favour of nicotine gum = 1.25, 95% confidence limits 0.47-3.31). The value of nicotine chewing gum, if any, can be quite small when it is used in general practice.