Smad-mediated regulation of microRNA biosynthesis.
Smad-mediated regulation of microRNA biosynthesis.
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SMAD介导的microRNA生物合成调节。
DOI：
10.1016/j.febslet.2012.01.041
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发表时间：
2012-07-04
期刊：
影响因子：
3.5
通讯作者：
Hata A
中科院分区：
文献类型：
--
作者：
Blahna MT;Hata A
microRNA（mirnas）是在Mirnas的耗尽中保守的小型非编码RNA。生长，分化和发育。反过来，众多蛋白质的表达通过转录和转录机制来调节miRNA的表达，以说明TGF-β的基因调节的复杂性。 。
MicroRNAs (miRNAs) are small non-coding RNAs conserved in metazoans. Depletion of miRNAs results in embryonic lethality, suggesting they are essential for embryogenesis. Similarly, pathways induced by growth factors of the transforming growth factor β (TGF-β) superfamily control cell growth, differentiation, and development. Recently Smad proteins, the signal transducers of the TGF-β pathway, were found to regulate miRNA expression, which, in turn, affects expression of numerous proteins. Smads modulate miRNA expression through both transcriptional and post-transcriptional mechanisms illustrating the complexity of gene regulation by TGF-β. In this chapter we summarize the current knowledge of mechanisms underlying Smad-mediated regulation of miRNA biogenesis.