Quantitative autoradiography of [3H]nitroimipramine binding sites in rat brain
Quantitative autoradiography of [3H]nitroimipramine binding sites in rat brain
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大鼠脑中[3H]硝基丙咪嗪结合位点的定量放射自显影
DOI：
10.1016/0006-8993(83)91026-0
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发表时间：
1983
期刊：
影响因子：
2.9
通讯作者：
A. Biegon
中科院分区：
文献类型：
--
作者：
T. Rainbow;A. Biegon
我们已经使用了最近的氚敏感的电影方法的定量放射自显影定位在大鼠脑中的高亲和力结合位点的硝基丙咪嗪（NI），一种持久的5-羟色胺（5-HT）的抑制剂在血小板的运输。大鼠脑内NI结合位点的分布与5-HT终末的分布密切相关。在中缝背核和内侧核、乳头核基底部、内侧前脑束、嗅结节和杏仁核后基底核中有高浓度的结合位点。[3 H]NI结合位点与5-HT含量高的区域的关联支持了这样的观点，即[3 H]NI的高亲和力结合位点对应于5-HT的突触前摄取位点的某些方面。
We have used the recent tritium-sensitive film method of quantitative autoradiography to localize in rat brain high-affinity binding sites for nitroimipramine (NI), a long-lasting inhibitor of serotonin (5-HT) transport in platlets. The distribution of NI binding sites in rat brain closely parallels the location of 5-HT terminals. There are high concentrations of binding sites in the dorsal and medial raphe nuclei, the basal portion of the mammilary nuclei, the medial forebrain bundle, the olfactory tubercule and the posterior basal nucleus of the amygdala. The association of [3H]NI binding sites with regions having a high content of 5-HT supports the notion that the high-affinity binding site for [3H]NI corresponding to some aspect of the presynaptic uptake site for 5-HT.
大鼠脑膜中去甲肾上腺素神经元摄取结合位点用[3H]地昔帕明标记。
DOI：
10.1073/pnas.78.8.5250
发表时间：
1981
影响因子：
11.1
作者：
Lee,CM;Snyder,SH
通讯作者：
Snyder,SH