Quantification of carotid atherosclerotic plaque components using feature space analysis and magnetic resonance imaging.
Quantification of carotid atherosclerotic plaque components using feature space analysis and magnetic resonance imaging.
复制标题
使用特征空间分析和磁共振成像对颈动脉粥样硬化斑块成分进行量化。
DOI：
10.1109/iembs.2006.260318
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Morrisett,JoelD
中科院分区：
文献类型：
--
作者：
Karmonik,Christof;Basto,Pamela;Morrisett,JoelD
动脉粥样硬化是心血管疾病的主要原因之一，占美国所有死亡人数的三分之一以上，越来越需要开发非侵入性技术来评估动脉粥样硬化斑块负担的严重程度。最近的研究表明，不是动脉粥样硬化斑块的大小，而是其组成表明斑块破裂是中风和急性冠状动脉综合征的潜在事件。由于其出色的软组织对比，磁共振成像（MRI）是检查斑块组成的首选方式。在一项离体研究中，为了证明在体内量化颈动脉粥样硬化斑块成分的可行性，我们利用市售的MRI序列和人体表面线圈获得了13个刚切除的动脉内膜组织的多对比MRI图像。在四个代表性组织中使用特征空间分析（FSA）来确定钙化，脂质，纤维化，血栓形成和正常成分的总相对丰度，以及在每个组织中穿过颈动脉分叉的连续2mm切片中。观察到FSA结果与组织学方法获得的结果之间具有良好的定性一致性。本研究证明MRI与FSA结合在体内量化颈动脉粥样硬化斑块的可行性
Atherosclerosis is one of the main causes of cardiovascular disease, accounting for more than one third of all deaths in the United States, there is a growing need to develop non-invasive techniques to assess the severity of atherosclerotic plaque burden. Recent research has suggested that not the size of the atherosclerotic plaque but rather its composition is indicative for plaque rupture as the underlying event of stroke and acute coronary syndrome. With its excellent soft-tissue contrast, magnetic resonance imaging (MRI) is a favored modality for examining plaque composition. In an ex-vivo study, aimed to show the feasibility of quantifying the components of carotid atherosclerotic plaques in-vivo, we acquired multi-contrast MRI images of 13 freshly excised endarterectomy tissues with commercially available MRI sequences and a human surface coil. Feature space analysis (FSA) was utilized in four representative tissues to determine the total relative abundance of calcific, lipidic, fibrotic, thrombotic and normal components as well as in consecutive 2 mm sections across the carotid bifurcation in each tissue. Excellent qualitative agreement between the FSA results and the results obtained from histological methods was observed. This study demonstrates the feasibility of combining MRI with FSA to quantify carotid atherosclerotic plaques in-vivo