MEASUREMENT OF TUMOR HYPOXIA BY INVASIVE AND NONINVASIVE PROCEDURES - A REVIEW OF RECENT CLINICAL-STUDIES
MEASUREMENT OF TUMOR HYPOXIA BY INVASIVE AND NONINVASIVE PROCEDURES - A REVIEW OF RECENT CLINICAL-STUDIES
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DOI：
10.1016/0167-8140(91)90181-f
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发表时间：
1991-01-01
影响因子：
5.7
通讯作者：
CHAPMAN, JD
中科院分区：
文献类型：
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作者：
CHAPMAN, JD
缺氧细胞在癌症治疗反应中的潜在重要性一直存在争议，因为它们在人类肿瘤中的存在是由Thomlinson和Gray的经典研究推断出来的。在体外和动物肿瘤研究中，含有低浓度分子氧的肿瘤细胞显示出对高能光子照射和某些化疗方案的抗性。目前还没有诊断程序可用于在诊断时或整个治疗过程中测量人类肿瘤的氧合状态。最近对氧电极和增敏剂加合物的研究表明，在人类实体肿瘤中，即使对于组织学和大小相似的肿瘤，氧水平也存在广泛的异质性。这些研究表明，为了确定肿瘤缺氧在治疗抵抗中的相对重要性，需要一种“预测性分析”来监测个体患者的肿瘤氧合状态。最近，一些测量肿瘤氧水平和肿瘤代谢的先进技术表明，肿瘤间和肿瘤内的肿瘤氧水平和其他代谢物具有异质性。虽然提供了有关人类肿瘤生物学的有用信息，但大多数侵入性手术并不适合作为标准诊断工具。核医学程序对致敏物加合物的无创测量和P-31核磁共振波谱法对肿瘤能量学的无创测量可能成为肿瘤氧合和可能治疗结果的常规预测指标。
The potential importance of hypoxic cells in cancer treatment response has been debated since their presence in human tumors was inferred by the classical studies of Thomlinson and Gray. Tumor cells which contain low concentrations of molecular oxygen display resistance to high energy photon irradiation and some chemotherapy regimens, in both in vitro and animal tumor studies. No diagnostic procedure is currently available for measuring the oxygenation status of human tumors at the time of diagnosis or throughout treatment. Recent studies with oxygen electrodes and sensitizer-adducts indicate a wide heterogeneity of oxygen levels within solid human tumors, even for tumors of similar histology and size. These studies suggest that to determine the relative importance of tumor hypoxia in treatment resistance, a "predictive assay" for monitoring tumor oxygenation status in individual patients will be required. Recently, several sophisticated techniques for measuring tumor oxygen levels and tumor metabolism have indicated both intertumor and intratumor heterogeneity of tumor oxygen levels and other metabolites. While providing useful information about human tumor biology, most of the invasive procedures are not appropriate as a standard diagnostic tool. Non-invasive measurements of 1) sensitizer-adducts by nuclear medicine procedures and 2) tumor energetics by P-31 NMR spectroscopy might be developed as routine predictors of tumor oxygenation and possible treatment outcome.