Chronic caffeine consumption exacerbates hypertension in rats with polycystic kidney disease
Chronic caffeine consumption exacerbates hypertension in rats with polycystic kidney disease
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DOI：
10.1053/ajkd.2001.28614
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发表时间：
2001-11-01
影响因子：
13.2
通讯作者：
Tanner, JA
中科院分区：
文献类型：
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作者：
Tanner, GA;Tanner, JA
常染色体显性多囊肾病（ADPKD）是一种常见的遗传性疾病，常伴有肾功能衰竭、高血压和其他异常。目前的研究确定慢性咖啡因摄入是否会影响肾脏结构和功能以及血压。从1月龄开始，向患有ADPKD的杂合子雄性Han：Sprague-Dawley大鼠和正常同窝大鼠提供自来水或咖啡因溶液饮用。当大鼠6月龄时，在Inactin（Byk Gulden，Konstanz，德国）麻醉下测量肾小球滤过率（GFR）和平均动脉血压（MAP）。咖啡因摄入对PKD大鼠的GFR或囊肿发育没有影响。PKD大鼠的MAP高于正常大鼠，咖啡因使其升高更明显。慢性咖啡因摄入的高血压效应不能归因于血管紧张素II的直接升压作用。根据我们的发现，咖啡因会加重PKD大鼠的高血压，在对人类进行研究之前，ADPKD患者将咖啡摄入量限制在每天四杯或更少杯咖啡可能是谨慎的。(C)2001年由国家肾脏基金会，公司。
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder frequently associated with renal failure, hypertension, and other abnormalities. The present study determined whether chronic caffeine intake in an animal model of this disease would affect renal structure and function and blood pressure. Heterozygous male Han:Sprague-Dawley rats with ADPKD and normal littermates were provided with either tap water or solutions of caffeine to drink, starting at 1 month of age. When rats were aged 6 months, glomerular filtration rate (GFR) and mean arterial blood pressure (MAP) were measured under Inactin (Byk Gulden, Konstanz, Germany) anesthesia. Caffeine intake had no effect on GFR or cyst development in rats with PKD. MAP was greater in rats with PKD than normal rats and was increased more by caffeine. The hypertensive effect of chronic caffeine intake could not be ascribed to direct pressor effects of angiotensin II. Based on our finding that caffeine exacerbates hypertension in rats with PKD, it may be prudent for patients with ADPKD to limit coffee consumption to four or fewer cups of caffeinated coffee per day, pending studies of humans. (C) 2001 by the National Kidney Foundation, Inc.