Preparation and Evaluation of Propranolol-Imprinted Monolithic Stationary Phase by In Situ Technique and Application in Analysis of Propranolol in Biological Samples
Preparation and Evaluation of Propranolol-Imprinted Monolithic Stationary Phase by In Situ Technique and Application in Analysis of Propranolol in Biological Samples
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DOI：
10.1080/00032710802677084
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发表时间：
2009-02
影响因子：
2
通讯作者：
Qianqian Zhang;Qiang Fu;Elijan Amut;Qiuxue Fang;Ai-guo Zeng;Chunran Chang
中科院分区：
文献类型：
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作者：
Qianqian Zhang;Qiang Fu;Elijan Amut;Qiuxue Fang;Ai-guo Zeng;Chunran Chang
Abstract A propranolol molecule-imprinted monolithic stationary phase (MIMSP) was synthesized by in situ technique. The recognition mechanism of the polymers and the influences of some chromatographic conditions were examined by high-performance liquid chromatography (HPLC). The imprinted polymers showed much higher selectivity for β-blockers than the nonimprinted polymers (NIPs) did, which proves the successful preparation of propranolol-imprinted polymers by using an in situ technique. Then, this technique was used to prepare a molecularly imprinted polymer solid-phase extraction column to concentrate propranolol from biological samples. The results showed that the imprinted solid-phase extraction column could selectively enrich and purify propranolol from biological samples, such as plasma.
