Current Status of Tissue-Engineered Scaffolds for Rotator Cuff Repair.
Current Status of Tissue-Engineered Scaffolds for Rotator Cuff Repair.
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DOI：
10.1097/bto.0000000000000168
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发表时间：
2016-06
期刊：
影响因子：
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通讯作者：
Little D
中科院分区：
文献类型：
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作者：
Chainani A;Little D
尽管使用了各种手术技术和增强器械，但肩袖撕裂仍然存在再次撕裂或手术修复后无法愈合的重大风险。因此，需要功能化支架策略，以在修复后的关键前12周期间提供持续的机械增强，并增强修复肌腱和肌腱-骨界面的愈合潜力。综述了联合收割机结合使用支架、细胞和生物活性分子的组织工程方法，以期为肩袖修复提供新的解决方案。理想的支架应具有足够的初始机械性能，缓慢降解或不可降解，具有无毒的降解产物，增强细胞生长、浸润和分化，促进肌腱-骨界面的再生，具有生物相容性，并具有优异的缝合保留和处理性能。与原生肩袖的不均匀性和非线性紧密匹配的支架可以显著地推进场。虽然大量的临床前工作仍有待完成，但在克服当前组织工程挑战方面的持续进展应允许成功的临床转化。
Rotator cuff tears continue to be at significant risk for re-tear or for failure to heal after surgical repair despite the use of a variety of surgical techniques and augmentation devices. Therefore, there is a need for functionalized scaffold strategies to provide sustained mechanical augmentation during the critical first 12-weeks following repair, and to enhance the healing potential of the repaired tendon and tendon-bone interface. Tissue engineered approaches that combine the use of scaffolds, cells, and bioactive molecules towards promising new solutions for rotator cuff repair are reviewed. The ideal scaffold should have adequate initial mechanical properties, be slowly degrading or non-degradable, have non-toxic degradation products, enhance cell growth, infiltration and differentiation, promote regeneration of the tendon-bone interface, be biocompatible and have excellent suture retention and handling properties. Scaffolds that closely match the inhomogeneity and non-linearity of the native rotator cuff may significantly advance the field. While substantial pre-clinical work remains to be done, continued progress in overcoming current tissue engineering challenges should allow for successful clinical translation.