Incidence of diagnosed polymyalgia rheumatica and temporal arteritis in the United Kingdom, 1990-2001
Incidence of diagnosed polymyalgia rheumatica and temporal arteritis in the United Kingdom, 1990-2001
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DOI：
10.1136/ard.2005.046912
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发表时间：
2006-08-01
影响因子：
27.4
通讯作者：
Hall, A. J.
中科院分区：
文献类型：
--
作者：
Smeeth, L.;Cook, C.;Hall, A. J.
目的：调查英国风湿性多肌痛 (PMR) 和颞动脉炎 (TA) 诊断发病率的时间趋势、地理差异和季节性。方法：分析英国全科医疗的计算机化医疗记录。参与者在 1990 年至 2001 年期间在全科医学研究数据库中注册。主要结果指标是按年份、年龄、性别、地理区域和日历月划分的诊断率。结果：在 17 830 028 人年的观察期间，有 15 013 人首次诊断为 PMR，3928 人首次诊断为 TA。年龄调整后的PMR发病率为8.4/万人年（95% CI 8.3～8.6），从1990年的6.9/万人年上升到2001年的9.3/万人年。年龄调整后的TA发病率为2.2/万人年（95% CI） 2.1 至 2.3），没有观察到增加。 PMR 和 TA 在英国南部比北部更常见，而且两者在夏季更常见。结论：对这些发现的解释尚不清楚。诊断实践和准确性的变化可能在一定程度上造成了所看到的模式。然而，这些发现也可能至少部分反映了疾病发病率的变化。这种引人注目的地理格局可能部分归因于英国南部和东部更为普遍的风险因素。
Objective: To investigate time trends, geographical variation, and seasonality in the incidence of diagnosis of polymyalgia rheumatica ( PMR) and temporal arteritis ( TA) in the United Kingdom.Methods: Analysis of computerised medical records from UK general practices. Participants were registered with a practice contributing to the General Practice Research Database during the period 1990 2001. The main outcome measures were rates of diagnosis by year, age, sex, geographical region, and calendar month.Results: 15 013 people had a first diagnosis of PMR and 3928 a first diagnosis of TA during 17 830 028 person-years of observation. The age adjusted incidence rate of PMR was 8.4/ 10 000 person-years ( 95% CI 8.3 to 8.6), rising from 6.9/10 000 person-years in 1990 to 9.3/10 000 in 2001. The age adjusted incidence rate of TA was 2.2/10 000 person-years ( 95% CI 2.1 to 2.3) with no increase observed. Both PMR and TA were more common in the south than in the north of the UK, and both were more commonly diagnosed in the summer months.Conclusions: The explanation for the findings is unclear. Variations in diagnostic practice and accuracy are likely to have contributed in part to the patterns seen. However, the findings are also likely to reflect, at least in part, variations in the incidence of disease. The striking geographical pattern may be partly attributable to a risk factor which is more prevalent in the south and east of the United Kingdom.