Syntheses of p-nitrophenyl 3-and 4-thio-β-D-glycopyranosides
Syntheses of p-nitrophenyl 3-and 4-thio-β-D-glycopyranosides
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DOI：
10.1016/j.carres.2010.10.001
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发表时间：
2010-12-10
影响因子：
3.1
通讯作者：
Withers, Stephen G.
中科院分区：
文献类型：
--
作者：
Chen, Hong-Ming;Withers, Stephen G.
巯基糖苷已被证明是一种有用的酶稳定的糖苷类似物，用于结构和机制的研究，并且通过使用巯基糖苷酶大大简化了它们的合成。作为研究巯基糖苷作为潜在的药理学伴侣和糖蛋白和糖脂成分的一部分，合成了对硝基苯基3-硫- β -d -半乳糖苷苯基1 - 4-二硫- β -d -葡萄糖吡喃苷对硝基苯基描述了4-硫- β -d -甘露糖pyranoside和对硝基苯基2-乙酰氨基-2-脱氧-4-硫- β -d -甘露糖pyranoside (C) 2010 Elsevier Ltd版权所有
Thioglycosides have proved to be useful enzymatically stable analogs of glycosides for structural and mechanistic studies and their synthesis is considerably simplified through the use of thioglycoligases As part of an investigation Into the use of thioglycosides as potential pharmacological chaperones and as components of glycoproteins and glycolipids the syntheses of p-nitrophenyl 3-thio-beta-D-galactopyranoside phenyl 1 4-dithio-beta-D-glucopyranoside p-nitrophenyl 4-thio-beta-D-mannopyranoside and p-nitrophenyl 2-acetamido-2-deoxy-4-thio-beta-D-mannopyranoside are described (C) 2010 Elsevier Ltd All rights reserved