Antioxidative enzyme activities and lipid peroxidation in major depression:: alterations by antidepressant treatments
Antioxidative enzyme activities and lipid peroxidation in major depression:: alterations by antidepressant treatments
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DOI：
10.1016/s0165-0327(00)00199-3
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发表时间：
2001-04-01
影响因子：
6.6
通讯作者：
Deger, O
中科院分区：
文献类型：
--
作者：
Bilici, M;Efe, H;Deger, O
背景：活性氧（ROS）可能在一些神经精神疾病中起作用。有证据表明，免疫炎症过程的激活、单胺分解代谢的增加和脂质化合物的异常可能导致ROS的过量产生，进而导致抗氧化酶活性（AEAs）和脂质过氧化（LP）的增加，这些现象可能与重度抑郁症的病理生理有关。方法：本研究的目的是：(i)检测重度抑郁症（MD）患者的AEAs和LP水平，并与健康对照进行比较；（ii）研究选择性血清素再摄取抑制剂（SSRIs）亚慢性治疗对MD患者AEAs和LP水平的影响。30例MD患者和32例健康对照（HC）参加了本研究。通过测定血浆和/或红细胞中的几种抗氧化酶和丙二醛（MDA）水平来测定AEAs和LP水平。结果：重度抑郁症患者，尤其是抑郁症患者的AEA和LP水平均高于正常对照组。经SSRIs治疗3个月后，患者的AEA和LP水平明显下降至正常水平。结论：这些研究结果表明：(1)重度抑郁症，尤其是抑郁症，与AEAs和LP升高有关，(2)亚慢性治疗SSRIs可能对AEA和LP有抑制作用。临床意义和局限性：AEAs可用于监测SSRIs的效果。(C) 2001 Elsevier Science B.V.版权所有
Background: Reactive oxygen species (ROS) may play a role in some neuropsychiatric disorders. There is some evidence that the activation of immune-inflammatory process, increase of monoamines catabolism, and abnormalities in lipid compounds may cause overproduction of ROS and, in turn, antioxidative enzyme activities (AEAs) and lipid peroxidation (LP), and that these phenomena may be related to pathophysiology of major depression. Methods: The aims of this study were (i) to examine the AEAs and LP levels of the major depressed (MD) patients, and to compare these with healthy controls; and (ii) to investigate the effect of subchronic treatment with selective serotonin reuptake inhibitors (SSRIs) on AEAs and LP levels in MD subjects, Thirty MD patients, and 32 healthy controls (HC) participated in this study. AEAs and LP levels were determined by measuring several antioxidative enzymes and malondialdehyde (MDA levels in plasma and/or in red blood cells. Results: Major depressed patients, especially melancholic patients, had higher AEA and LP levels than those of healthy controls. After treatment for 3 months with SSRIs, AEA and LP levels of the patients were significantly decreased to normal levels. Conclusion: These findings suggest that (i) major depression, especially with melancholia, is associated with elevated AEAs and LP, and that (ii) subchronic treatment with SSRIs may have a suppressive effect on AEA and LP. Clinical implication and limitation: AEAs might be used for monitoring SSRIs effects. (C) 2001 Elsevier Science B.V. All rights reserved.