Select aging biomarkers based on telomere length and chronological age to build a biological age equation
Select aging biomarkers based on telomere length and chronological age to build a biological age equation
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DOI：
10.1007/s11357-014-9639-y
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发表时间：
2014-03
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影响因子：
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通讯作者：
Weiguang Zhang;Shu-Ying Zhu;X. Bai;Delong Zhao;Shimin Jiang;Juan Li;Zuoxiang Li;B. Fu;G. Cai;Xuefeng Sun;Xiang-mei Chen
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文献类型：
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作者：
Weiguang Zhang;Shu-Ying Zhu;X. Bai;Delong Zhao;Shimin Jiang;Juan Li;Zuoxiang Li;B. Fu;G. Cai;Xuefeng Sun;Xiang-mei Chen
本研究的目的是建立一个结合端粒长度与实足年龄（CA）及相关衰老生物标志物的生物年龄（BA）方程。总共从北京的汉族人群中招募了139名健康志愿者。测定并分析遗传指标、肾功能指标、心血管功能指标、脑功能指标、氧化应激和炎症指标（c -反应蛋白[CRP]）。以端粒限制性内切片段（TRF）和CA为主要成分，建立了基于选定参数的BA方程。选择的衰老指标包括二尖瓣环E峰前壁（MVEA）、内膜-中膜厚度（IMT）、胱抑素C （CYSC）、d -二聚体（DD）和数字符号测试（DST）。英航方程是:英航基金会=−2.281 + 26.321 cysc mvea−104.419 + 34.863 + 0.025 dd imt−0.265 dst + 0.305 + 26.346。综上所述，端粒长度和CA作为双基准可能是构建BA的新方法。
The purpose of this study is to build a biological age (BA) equation combining telomere length with chronological age (CA) and associated aging biomarkers. In total, 139 healthy volunteers were recruited from a Chinese Han cohort in Beijing. A genetic index, renal function indices, cardiovascular function indices, brain function indices, and oxidative stress and inflammation indices (C-reactive protein [CRP]) were measured and analyzed. A BA equation was proposed based on selected parameters, with terminal telomere restriction fragment (TRF) and CA as the two principal components. The selected aging markers included mitral annulus peak E anterior wall (MVEA), intima-media thickness (IMT), cystatin C (CYSC), D-dimer (DD), and digital symbol test (DST). The BA equation was: BA = −2.281TRF + 26.321CYSC + 0.025DD − 104.419MVEA + 34.863IMT − 0.265DST + 0.305CA + 26.346. To conclude, telomere length and CA as double benchmarks may be a new method to build a BA.