Sparse and distributed cortical populations mediate sensorimotor integration.
Sparse and distributed cortical populations mediate sensorimotor integration.
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稀疏且分布的皮质群介导感觉运动整合。
DOI：
10.1101/2023.09.21.558857
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Peron,Simon
中科院分区：
文献类型：
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作者：
Pancholi,Ravi;Sun-Yan,Andrew;Laughton,Maya;Peron,Simon
触觉信息是感觉运动整合的核心，但对皮层触觉和运动表征如何相互作用知之甚少。触觉和运动相关的活动存在于躯体感觉和运动皮层中，使这两个候选网站的触摸运动的相互作用。我们研究了触摸运动的相互作用，在第2/3层的初级触须体感和运动皮层的行为小鼠。体积双光子钙成像显示强大的反应，胡须触摸，搅拌，舔在这两个领域。触摸活动占主导地位的稀疏人口广泛调谐神经元响应多个胡须，表现出纵向稳定性和不成比例地影响interareal通信。运动表征同样由稀疏、稳定、非投射的种群主导。在这两个区域，许多广泛调谐的触摸细胞也产生了强烈的舔或拂反应。这些触摸舔和触摸拂动神经元表现出不同的动力学，暗示了在塑造运动中的特定作用。因此，皮层触摸-运动相互作用是由高度反应的、广泛调谐的神经元的专门群体介导的。
Touch information is central to sensorimotor integration, yet little is known about how cortical touch and movement representations interact. Touch- and movement-related activity is present in both somatosensory and motor cortices, making both candidate sites for touch-motor interactions. We studied touch-motor interactions in layer 2/3 of the primary vibrissal somatosensory and motor cortices of behaving mice. Volumetric two-photon calcium imaging revealed robust responses to whisker touch, whisking, and licking in both areas. Touch activity was dominated by a sparse population of broadly tuned neurons responsive to multiple whiskers that exhibited longitudinal stability and disproportionately influenced interareal communication. Movement representations were similarly dominated by sparse, stable, reciprocally projecting populations. In both areas, many broadly tuned touch cells also produced robust licking or whisking responses. These touch-licking and touch-whisking neurons showed distinct dynamics suggestive of specific roles in shaping movement. Cortical touch-motor interactions are thus mediated by specialized populations of highly responsive, broadly tuned neurons.