Regioselective C5-H direct iodination of indoles
Regioselective C5-H direct iodination of indoles
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DOI：
10.1039/d1qo00105a
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发表时间：
2021-04
影响因子：
5.4
通讯作者：
Zhaoli Wang;Rui-Li Guo;Xing-Long Zhang;Meng-Yue Wang;Gang Chen;Yong-Qiang Wang
中科院分区：
文献类型：
--
作者：
Zhaoli Wang;Rui-Li Guo;Xing-Long Zhang;Meng-Yue Wang;Gang Chen;Yong-Qiang Wang
An efficient highly regioselective C5-H direct iodination of indoles is reported herein for the first time. Due to the versatility of aryl iodides, the method offers a general and practical access to the C5 functionalization of indoles. The approach features mild reaction conditions, good tolerance of functional groups, and more crucially, no metal involved in the reaction, thereby benefitting the late-stage decoration of medicinal molecules. A mechanistic study showed that the current iodination reaction proceeded via a radical pathway.
