Ferroptosis and Acute Kidney Injury (AKI): Molecular Mechanisms and Therapeutic Potentials.
Ferroptosis and Acute Kidney Injury (AKI): Molecular Mechanisms and Therapeutic Potentials.
复制标题
铁死亡和急性肾损伤 (AKI)：分子机制和治疗潜力
DOI：
10.3389/fphar.2022.858676
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发表时间：
2022
影响因子：
5.6
通讯作者：
Yang, Yang
中科院分区：
文献类型：
--
作者：
Feng, Qi;Yu, Xiaoyue;Qiao, Yingjin;Pan, Shaokang;Wang, Rui;Zheng, Bin;Wang, Hui;Ren, Kai-Di;Liu, Hui;Yang, Yang
急性肾损伤（acute kidney injury，阿基）是一种常见的严重的临床肾脏综合征，发病率和死亡率高，是由多种致病因素引起的，如缺血、肾毒性药物、氧化应激、炎症、尿路梗阻等。细胞死亡分为几种类型，对正常生长发育和维持动态平衡至关重要。铁凋亡是一种铁依赖性非凋亡性细胞死亡，其特征是铁超载、活性氧积累和脂质过氧化。最近，越来越多的证据表明铁缺乏在各种肾脏疾病（包括肾透明细胞癌、糖尿病肾病和阿基）的发展中发挥重要作用。然而，铁凋亡参与阿基发生和发展的确切机制尚未完全揭示。在此，我们的目标是系统地讨论铁凋亡的定义、相关机制和关键调节因子以及药理学进展，并总结有关铁凋亡在阿基发展中的作用和机制的最新发现。我们进一步总结了其在阿基中的潜在治疗策略。
Acute kidney injury (AKI), a common and serious clinical kidney syndrome with high incidence and mortality, is caused by multiple pathogenic factors, such as ischemia, nephrotoxic drugs, oxidative stress, inflammation, and urinary tract obstruction. Cell death, which is divided into several types, is critical for normal growth and development and maintaining dynamic balance. Ferroptosis, an iron-dependent nonapoptotic type of cell death, is characterized by iron overload, reactive oxygen species accumulation, and lipid peroxidation. Recently, growing evidence demonstrated the important role of ferroptosis in the development of various kidney diseases, including renal clear cell carcinoma, diabetic nephropathy, and AKI. However, the exact mechanism of ferroptosis participating in the initiation and progression of AKI has not been fully revealed. Herein, we aim to systematically discuss the definition of ferroptosis, the associated mechanisms and key regulators, and pharmacological progress and summarize the most recent discoveries about the role and mechanism of ferroptosis in AKI development. We further conclude its potential therapeutic strategies in AKI.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
4
作者：
Dixon SJ;Winter GE;Musavi LS;Lee ED;Snijder B;Rebsamen M;Superti-Furga G;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
1.7
作者：
Daher, R.;Karim, Z.
通讯作者：
Karim, Z.
影响因子：
21.3
作者：
Friedmann Angeli JP;Schneider M;Proneth B;Tyurina YY;Tyurin VA;Hammond VJ;Herbach N;Aichler M;Walch A;Eggenhofer E;Basavarajappa D;Rådmark O;Kobayashi S;Seibt T;Beck H;Neff F;Esposito I;Wanke R;Förster H;Yefremova O;Heinrichmeyer M;Bornkamm GW;Geissler EK;Thomas SB;Stockwell BR;O'Donnell VB;Kagan VE;Schick JA;Conrad M
通讯作者：
Conrad M
DOI：
10.1016/j.bbrc.2020.01.066
发表时间：
2020-03-19
影响因子：
3.1
作者：
Dai, Enyong;Zhang, Wenlong;Tang, Daolin
通讯作者：
Tang, Daolin