Identification of novel cell-wall active antifungal compounds.
Identification of novel cell-wall active antifungal compounds.
复制标题
新型细胞壁活性抗真菌化合物的鉴定。
DOI：
10.1016/j.ijantimicag.2006.07.006
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发表时间：
2006
影响因子：
10.8
通讯作者：
Selitrennikoff,ClaudeP
中科院分区：
文献类型：
--
作者：
StGeorge,Stephanie;Selitrennikoff,ClaudeP
人类和其他动物的真菌感染是严重的，往往危及生命，特别是免疫功能低下的患者。治疗真菌疾病的一个困难是抗真菌化合物的药库有限。最近三种细胞壁活性抗真菌化合物的监管批准鼓励寻找其他抑制真菌细胞壁形成的临床候选药物。我们已经筛选了一个独特的化学文库的一小部分，并发现了八种化合物，似乎是真菌细胞壁组装的抑制剂。
Fungal infections of humans and other animals are serious and often life threatening, especially in immunocompromised patients. One difficulty in treating fungal disease is the limited arsenal of antifungal compounds. The recent regulatory approval of three cell-wall active antifungal compounds encourages the search for additional clinical candidates that inhibit fungal cell wall formation. We have screened a small portion of a unique chemical library and have found eight compounds that appear to be inhibitors of fungal cell wall assembly.