Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: Data from mutant and genetically modified mice
Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: Data from mutant and genetically modified mice
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DOI：
10.1016/j.mce.2008.11.005
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发表时间：
2009-07-10
影响因子：
4.1
通讯作者：
Abel, M. H.
中科院分区：
文献类型：
--
作者：
O'Shaughnessy, P. J.;Morris, I. D.;Abel, M. H.
雄性表型的发育和维持以及生殖能力的建立都依赖于睾丸支持细胞和睾丸间质细胞的活性。本文综述了这些细胞在胎儿和出生后发育过程中的调节和功能。胎儿间质细胞对促黄体生成素（LH）和促肾上腺皮质激素（ACTH）均敏感，但缺乏这两种激素或其受体的胎儿小鼠间质细胞功能正常。出生后，支持细胞和间质细胞依赖于垂体促性腺激素。间质细胞严重依赖于LH，但卵泡刺激素（FSH）可能通过支持细胞起作用，也会影响间质细胞的功能。睾丸素由间质细胞分泌，与卵泡刺激素共同作用，刺激支持细胞活性和精子发生。对缺乏fsh受体和雄激素受体的动物的研究表明，这两种激素都可以维持减数分裂生殖细胞的数量，但雄激素对完成减数分裂至关重要。(C) 2008年由爱思唯尔爱尔兰有限公司出版
Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis. This review examines the regulation and function of these cell during fetal and post-natal development. Fetal Leydig cells are sensitive to both luteinising hormone (LH) and adrenocorticotrophic hormone (ACTH) but Leydig cell function appears normal in fetal mice lacking both hormones or their receptors. Post-natally, the Sertoli cells and Leydig cells are reliant upon the pituitary gonadotrophins. Leydig cells are critically dependent on LH but follicle-stimulating hormone (FSH), presumably acting through the Sertoli cell, can also affect Leydig cell function. Testosterone secreted by the Leydig cells acts with FSH to stimulate Sertoli cell activity and spermatogenesis. Study of animals lacking FSH-receptors and androgen-receptors shows that both hormones can act to maintain the meiotic germ cell population but that androgens are critical for completion of meiosis. (C) 2008 Published by Elsevier Ireland Ltd