A colloid approach to decorate latex particles with Prussian blue nanozymes
A colloid approach to decorate latex particles with Prussian blue nanozymes
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DOI：
10.1016/j.molliq.2020.113066
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发表时间：
2020-07-01
影响因子：
6
通讯作者：
Szilagyi, Istvan
中科院分区：
文献类型：
--
作者：
Alsharif, Nizar B.;Samu, Gergely F.;Szilagyi, Istvan
采用共沉淀法制备了具有过氧化物酶和超氧化物歧化酶活性的普鲁士蓝（PB）纳米粒子，并将其固定在脒功能化的聚苯乙烯乳胶（AL）粒子上。通过测定样品中的荷电和聚集特性，评估了在不同质量比下Al和PB颗粒之间的相互作用以及所得AL-PB杂化复合材料的胶体稳定性。带负电荷的PB纳米颗粒强烈吸附在带相反电荷的AL颗粒上，一旦PB剂量增加，就会产生一系列具有正、中性和负总电荷的AL-PB复合物。在Al颗粒表面形成饱和PB层的AL-PB复合物形成相当稳定的分散体。此外，通过电子显微镜和酶分析，探讨了AL-PB复合材料的形态，结构和功能特征。结果表明，PB纳米粒子的固定化不仅提供了一个持续的催化表面，但不损害酶的活性。所获得的稳定复合物是抗氧化疗法中的有前途的试剂，并且无论其目的是在实验室或更大规模上减少氧化应激。(C)2020年，任作家。由爱思唯尔公司出版
Prussian blue (PB) nanoparticles of intrinsic peroxidase and superoxide dismutase-like activities were prepared by the co-precipitation method and immobilized on amidine functionalized polystyrene latex (AL) particles. The interaction between the AL and PB particles and the colloidal stability of the resulting AL-PB hybrid composites were assessed at different mass ratios via determination of the charging and aggregation characteristics in the samples. The negatively charged PB nanoparticles strongly adsorbed on the oppositely charged AL particles resulting in a range of AL-PB composites of positive, neutral and negative overall charge, once the PB dose was increased. The AL-PB composite of a saturated PB layer on the surface of the AL particles formed considerably stable dispersions. Further, the morphology, structural and functional features of the AL-PB composites were explored by electron microscopy and enzymatic assays. The results revealed that the immobilization of PB nanoparticles not only provided a sustained catalytic surface but did not compromise the enzyme-like activities. The obtained stable composite is a promising agent in antioxidant therapies and wherever the aim is to reduce oxidative stress at laboratory or larger scales. (C) 2020 The Authors. Published by Elsevier B.V.