Atmospheric PM2.5-bound polycyclic aromatic hydrocarbons in China's four cities: Characterization, risk assessment, and epithelial-to-mesenchymal transition induced by PM2.5
Atmospheric PM2.5-bound polycyclic aromatic hydrocarbons in China's four cities: Characterization, risk assessment, and epithelial-to-mesenchymal transition induced by PM2.5
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中国四个城市大气中 PM2.5 结合的多环芳烃：特征、风险评估以及 PM2.5 诱导的上皮间质转化
DOI：
10.1016/j.apr.2021.101122
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发表时间：
2021-07
影响因子：
4.5
通讯作者：
Nan Sang
中科院分区：
文献类型：
--
作者：
Nan Nan;Huiling Duan;Xiaofeng Yang;Lei Wang;Aiqin Liu;Rui Chen;Guohua Qin;Nan Sang
城市颗粒物（PM）的化学成分对人体健康影响突出，总体上具有明显的区域差异特征。在PM的复合成分中，多环芳烃（PAHs）因其较高的致癌性值得专门研究。本研究采集了太原、北京、杭州和广州4个城市4个季节的pm2.5样本，对其中18种多环芳烃的浓度进行了测定和分析。结果表明，太原和北京的PM中PAHs浓度显著高于杭州和广州。采用终生癌症风险增量（ILCR）模型进行健康风险评价，结果显示太原市空气中多环芳烃致癌风险最高，4个城市冬季空气中多环芳烃风险值均超过WHO健康指导值。体外实验表明，4个城市冬季pm2.5对A549细胞有不同程度的迁移和侵袭作用。体内实验表明，来自四个城市的冬季pm2.5引发C57BL/6小鼠上皮间质转化（epithelial -to- mesenchal Transition， EMT）标志物表达改变。
The chemical composition of particulate matter (PM) in urban area is prominent for the human health and generally takes a clear regional difference character. Among the complex components of PM, polycyclic aromatic hydrocarbons (PAHs) are deserved to be specifically investigated from the reason of their high carcinogenic ability. In this study, PM2.5samples were collected from Taiyuan, Beijing, Hangzhou, and Guangzhou in four seasons, and the concentrations of 18 PAHs were measured and analyzed. The results indicated that PAHs concentrations were significantly higher in PM from Taiyuan and Beijing than those from Hangzhou and Guangzhou. According to the health risk assessment using incremental lifetime cancer risk (ILCR) model, the cancer risk of PAHs of PM from Taiyuan was the highest, and the risk values of PAHs of PM in winter of four cities exceeded the WHO health-based guideline value.In vitroexperiments indicated that winter PM2.5from four cities induced varying degrees of migration and invasion in A549 cells.In vivoexperiments indicated that winter PM2.5from four cities triggered altered expressions of Epithelial-to-mesenchymal Transition (EMT) markers in C57BL/6 mice.
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影响因子：
8.8
作者：
Junyan Yan;Lifang Jin;Derong Lin;C. Lai;Zhongjuan Xu;Renjun Wang;Yi‐Chun Chen;Baowei Hu;Chia‐Hua Lin
通讯作者：
Junyan Yan;Lifang Jin;Derong Lin;C. Lai;Zhongjuan Xu;Renjun Wang;Yi‐Chun Chen;Baowei Hu;Chia‐Hua Lin
影响因子：
9.8
作者：
Chang, Junrui;Shen, Jianing;Wang, Qin
通讯作者：
Wang, Qin
影响因子：
13.6
作者：
Kong, Shaofei;Ding, Xiao;Li, Zhiyong
通讯作者：
Li, Zhiyong
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
Renjie Chen;H. Kan;Bing-heng Chen;Wei Huang;Z. Bai;G. Song;G. Pan
通讯作者：
Renjie Chen;H. Kan;Bing-heng Chen;Wei Huang;Z. Bai;G. Song;G. Pan
影响因子：
5.8
作者：
Duan, X.;Wang, B.;Tao, S.
通讯作者：
Tao, S.