Dopamine D2, D3, and D4 receptor mRNA levels in rat brain and pituitary during aging
Dopamine D2, D3, and D4 receptor mRNA levels in rat brain and pituitary during aging
复制标题
衰老过程中大鼠大脑和垂体中多巴胺 D2、D3 和 D4 受体 mRNA 水平
DOI：
10.1016/0197-4580(94)90053-1
复制
发表时间：
1994
影响因子：
4.2
通讯作者：
P. Spano
中科院分区：
文献类型：
--
作者：
A. Valerio;M. Belloni;M. L. Gorno;C. Tinti;M. Memo;P. Spano
采用逆转录聚合酶链反应技术测定了6、12、18和24月龄大鼠不同脑区D2家族不同受体编码mRNA的水平。我们发现，在纹状体，黑质和额叶皮质的D2short和D2long受体的mRNA水平进行性，年龄依赖性的减少。海马和嗅结节中D2short和D2long受体mRNA水平无变化，而垂体中D2short和D2long受体mRNA水平升高。D3受体mRNA水平在嗅结节中降低，而在纹状体中无变化。垂体中D4受体mRNA水平未改变。这些数据表明，负责调节各种多巴胺受体的表达模式的分子机制受到衰老的差异调节。
Reverse Transcriptase-Polymerase Chain Reaction technique was used to determine the levels of the mRNAs encoding different receptors belonging to the D2family in various brain areas of 6-, 12-, 18-, and 24-month-old rats. We found a progressive, age-dependent reduction in the mRNA levels of D2short and D2long receptors in corpus striatum, substantia nigra, and frontal cortex. D2short and D2long receptor mRNA levels were unchanged in hippocampus and olfactory tubercle, while they increased in pituitary. D3receptor mRNA levels were reduced in olfactory tubercle and unchanged in striatum. D4receptor mRNA levels were unmodified in pituitary gland. These data suggest that the molecular mechanisms responsible for regulating the pattern of expression of the various dopamine receptors are differentially regulated by aging.
DOI：
10.1073/pnas.87.11.4078
发表时间：
1990-06-01
影响因子：
11.1
作者：
IACOPINO, AM;CHRISTAKOS, S
通讯作者：
CHRISTAKOS, S
大鼠多巴胺 D4 受体：序列、基因结构和心血管系统中的表达演示。
DOI：
--
发表时间：
1992
期刊：
The New biologist
影响因子：
--
作者：
O'Malley,KL;Harmon,S;Tang,L;Todd,RD
通讯作者：
Todd,RD