Accelerated 3D echo-planar imaging with compressed sensing for time-resolved hyperpolarized 13C studies
Accelerated 3D echo-planar imaging with compressed sensing for time-resolved hyperpolarized 13C studies
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DOI：
10.1002/mrm.26125
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发表时间：
2017-02-01
影响因子：
3.3
通讯作者：
Cunningham, Charles H.
中科院分区：
文献类型：
--
作者：
Geraghty, Benjamin J.;Lau, Justin Y. C.;Cunningham, Charles H.
目的为了实现大视场，超极化C-13代谢成像中的时间分辨体积覆盖率通过实施基于压缩感知框架的新型数据采集和图像重建方法来实现。MethodsA用于单共振激发的频谱空间脉冲，随后是对称回波平面成像（EPI）读出，用于在5 x 5 mm（2）处编码72 x 18 cm（2）的视场。分辨率在回波平面成像读出的斜坡部分期间，利用闪烁z梯度实现随机欠采样。序列和重建进行了测试与幻影研究和连续在体内超极化C-13扫描大鼠。在重建图像的结构相似性和定量的乳酸-丙酮酸比在大鼠kidney.ResultsNo伪影或分辨率损失的基础上，retroperitively和前瞻性欠采样数据进行了比较，在压缩感知重建图像与建议的序列中获得的是明显的。结构相似性分析表明，压缩感知重建可以准确地恢复代谢imagesevaluated.ConclusionA新的Z-光点采集序列压缩感知加速超极化C-13三维回波平面成像的空间特征的开发和证明。从大鼠的回顾性和前瞻性欠采样数据的乳酸-丙酮酸比的密切协议表明，代谢信息保存与加速因子高达3倍与发达的方法。Magn Reson Med 77：538-546，2017。(c)2016年国际医学磁共振学会
PurposeTo enable large field-of-view, time-resolved volumetric coverage in hyperpolarized C-13 metabolic imaging by implementing a novel data acquisition and image reconstruction method based on the compressed sensing framework.MethodsA spectral-spatial pulse for single-resonance excitation followed by a symmetric echo-planar imaging (EPI) readout was implemented for encoding a 72 x 18 cm(2) field of view at 5 x 5 mm(2) resolution. Random undersampling was achieved with blipped z-gradients during the ramp portion of the echo-planar imaging readout. The sequence and reconstruction were tested with phantom studies and consecutive in vivo hyperpolarized C-13 scans in rats. Retrospectively and prospectively undersampled data were compared on the basis of structural similarity in the reconstructed images and the quantification of the lactate-to-pyruvate ratio in rat kidneys.ResultsNo artifacts or loss of resolution are evident in the compressed sensing reconstructed images acquired with the proposed sequence. Structural similarity analysis indicate that compressed sensing reconstructions can accurately recover spatial features in the metabolic images evaluated.ConclusionA novel z-blip acquisition sequence for compressed sensing accelerated hyperpolarized C-13 3D echo-planar imaging was developed and demonstrated. The close agreement in lactate-to-pyruvate ratios from both retrospectively and prospectively undersampled data from rats shows that metabolic information is preserved with acceleration factors up to 3-fold with the developed method. Magn Reson Med 77:538-546, 2017. (c) 2016 International Society for Magnetic Resonance in Medicine