Acute viral hepatitis in Hanoi, Viet Nam
Acute viral hepatitis in Hanoi, Viet Nam
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DOI：
10.1016/s0035-9203(96)90418-6
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发表时间：
1996-11-01
影响因子：
2.2
通讯作者：
Hyams, KC
中科院分区：
文献类型：
--
作者：
Corwin, AL;Dai, TC;Hyams, KC
1993年1月至1995年2月在越南河内进行了一项急性肝炎的研究，用酶联免疫吸附试验对188份临床肝炎病例血清进行了抗甲型肝炎病毒（HAV）的免疫球蛋白（IG）M、抗B型肝炎核心抗原（HBc）的IgM、抗丙型肝炎病毒（HCV）的IgG、抗戊型肝炎病毒（HEV）的IgG和抗HEV的IgM的筛查。此外，187名对照受试者的血清，年龄，性别和入院月份相匹配，最近没有肝炎史，进行了比较。在53%的病例（2例混合感染）中有近期HAV（29%）和B型肝炎病毒（24%）感染的血清学证据，而对照组为2%。在10%的病例（无IgM抗HAV或IgM抗HBc）和1%的对照血清中检测到HCV感染。有没有显着差异的比例IgG抗-HEV阳性的情况下（在IgM抗-HAV或IgM抗-HBc的情况下）（21%）和对照组（14%），所有病例血清中3%的IgM抗-HEV阳性。年轻的案例（
A study of acute hepatitis was conducted in Hanoi, Viet Nam, from January 1993 to February 1995; 188 sera from clinical hepatitis cases were screened by enzyme-linked immunosorbent assay for immunoglobulin (Ig) M anti-hepatitis A virus (HAV), IgM anti-hepatitis B core antigen (HBc), IgG anti-hepatitis C virus (HCV), IgG anti-hepatitis E virus (HEV) and IgM anti-HEV. Additionally, 187 sera from control subjects, matched by age, sex and month of admission, with no recent history of hepatitis, were tested for comparative purposes. There was serological evidence of recent HAV (29%) and hepatitis B virus (24%) infection in 53% of cases (2 mixed infections), compared with 2% of controls. HCV infections were detected in 10% of cases (with no IgM anti-HAV or IgM anti-HBc) and in 1% of control sera. There was no significant difference in the proportion of IgG anti-HEV positive sera between cases (in the absence of IgM anti-HAV or IgM anti-HBc) (21%) and controls (14%); 3% of all case sera were IgM anti-HEV positive. Younger cases (