RAPIDITY OF SYMPTOM REDUCTION IN DEPRESSIONS TREATED WITH AMITRIPTYLINE
RAPIDITY OF SYMPTOM REDUCTION IN DEPRESSIONS TREATED WITH AMITRIPTYLINE
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阿米替林治疗抑郁症症状迅速减轻
DOI：
10.1097/00005053-197501000-00005
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
Brigitte Pkusoff
中科院分区：
文献类型：
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作者：
D. Haskell;A. Dimascio;Brigitte Pkusoff
研究人员对一组接受阿米替林治疗的抑郁症女性进行了研究，特别关注与神经症抑郁症患者相比，抑郁症和精神病患者不同症状的反应速度。研究结果显示，自杀情绪、失眠和厌食症的改善较快，但工作和兴趣受损、迟钝、悲观和绝望的改善较缓慢且渐进。精神病性抑郁症直到治疗第三周才显示出实质性改善，而神经性抑郁症在治疗第一周内就显着改善。有人建议，精神病分类作为反应速度的预测因子可能比作为最终治疗结果的预测因子更有用。
A group of depressed women treated with amitriptyline was studied with particular attention to the speed of response in different symptoms of depression and in psychotic as compared to neurotic depressives. The findings showed rapid improvement in suicidal feelings, insomnia, and anorexia, but slower and more gradual improvement in impaired work and interests, retardation and pessimism and hopelessness. Psychotic depressives did not show substantial improvement until the third week of treatment whereas neurotic depressives improved markedly within the first week. It is suggested that the psychotic classification may be more useful as a predictor of speed of response than as a predictor of final treatment outcome.