Profiling the gene signature of endometrial receptivity: clinical results
Profiling the gene signature of endometrial receptivity: clinical results
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DOI：
10.1016/j.fertnstert.2012.12.005
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发表时间：
2013-03-01
影响因子：
6.7
通讯作者：
Simon, Carlos
中科院分区：
文献类型：
--
作者：
Garrido-Gomez, Tamara;Ruiz-Alonso, Maria;Simon, Carlos
本文强调需要客观地诊断子宫内膜容受性作为导致女性患者不孕的一个因素的方法。通过使用子宫内膜容受性生物标志物，正确识别特定患者的适当植入窗口，有助于预防因子宫内膜植入窗口 (WOI) 时机错误而导致的生殖失败。尽管迄今为止还没有鉴定出能够指示子宫内膜容受性状态的单一临床相关形态学、分子或组织学标记，但过去十年对人类子宫内膜进行的全局转录组分析使我们深入了解了能够识别子宫内膜容受性的基因组特征。因此，开发了一种基于定制微阵列的名为子宫内膜容受性阵列 (ERA) 的基因组工具，并创建了经过专门训练的生物信息预测计算机算法来识别子宫内膜中的 WOI 时间。事实证明，该工具在确定个性化 WOI 日方面比组织学 (Noyes) 约会更准确、更一致，从而催生了在子宫内膜容受性最佳日进行个性化 ET 的新临床概念，并根据具体情况进行确定。 （Fertil Steril (R) 2013；99:1078-85。(C) 2013，美国生殖医学会。）
This article highlights the need for methods to objectively diagnose endometrial receptivity as a factor contributing to infertility in female patients. The correct identification of the appropriate window of implantation in a given patient, by using endometrial receptivity biomarkers, can help to prevent reproductive failure resulting from misplaced timing of the endometrial window of implantation (WOI). Although to date no single, clinically relevant morphologic, molecular, or histologic marker capable of indicating endometrial receptivity status has been identified, global transcriptomic analysis of human endometria performed in the last decade has given us insights into a genomic signature that is capable of identifying endometrial receptivity. As a consequence, a genomic tool named the Endometrial Receptivity Array (ERA), based on a customized microarray, was developed, and along with it a specially trained bioinformatic prediction computer algorithm was created to identify WOI timing in the endometrium. This tool has proven more accurate and consistent than histologic (Noyes) dating at identifying the personalized WOI day, thus leading to the new clinical concept of personalized ET on the optimum day of endometrial receptivity, identified individually case by case. (Fertil Steril (R) 2013;99:1078-85. (C) 2013 by American Society for Reproductive Medicine.)