Transcriptional control of invariant NKT cell development.
Transcriptional control of invariant NKT cell development.
复制标题
DOI：
10.1111/j.1600-065x.2010.00962.x
复制
发表时间：
2010-11
影响因子：
8.7
通讯作者：
Nichols KE
中科院分区：
文献类型：
--
作者：
Das R;Sant'Angelo DB;Nichols KE
不变自然杀伤 T (iNKT) 细胞由罕见的淋巴细胞亚系组成，其表型和功能特性与 T 和 NK 细胞相似。与传统的 αβ T 细胞类似，它们的发育主要发生在胸腺中，源自 CD4+CD8+ 双阳性 (DP) 祖细胞。然而，iNKT 细胞的选择是独特的，因为它是由 DP 细胞的同型相互作用和糖脂抗原-CD1d 复合物的识别介导的。此外，iNKT 细胞在发育过程中获得激活的先天样表型，使它们能够在抗原暴露后快速释放细胞因子。鉴于 iNKT 细胞的混合特征，iNKT 细胞的发育程序与 T 细胞和 NK 细胞的发育程序部分重叠也就不足为奇了。最近的几份报告对指导 NKT 细胞谱系定型和成熟的发育机制提供了令人兴奋的新见解。在这篇综述中，我们讨论了 NKT 细胞发育程序，重点关注影响该谱系个体发育的信号传导机制和转录因子。对这些转录因子复杂的相互作用及其与其他细胞外和细胞内信号分子的关系的持续研究无疑将为了解这种不寻常的 T 细胞谱系的生物学提供重要线索。
Invariant natural killer T (iNKT) cells comprise a rare lymphocyte sublineage with phenotypic and functional properties similar to T and NK cells. Akin to conventional αβ T cells, their development occurs primarily in the thymus, where they originate from CD4+CD8+ double positive (DP) progenitors. However, the selection of iNKT cells is unique in that it is mediated by homotypic interactions of DP cells and recognition of glycolipid antigen-CD1d complexes. Additionally, iNKT cells acquire an activated innate-like phenotype during development that allows them to release cytokines rapidly following antigen exposure. Given their hybrid features, it is not surprising that the developmental program of iNKT cells partially overlaps with that of T and NK cells. Several recent reports have provided new and exciting insights into the developmental mechanisms that direct NKT cell lineage commitment and maturation. In this review, we provide a discussion of the NKT cell developmental program with an emphasis on the signaling mechanisms and transcription factors that influence the ontogeny of this lineage. Continued investigations of the complex interplay of these transcription factors and their relationship with other extracellular and intracellular signaling molecules will undoubtedly provide important clues into the biology of this unusual T-cell lineage.